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Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10667-5 The Pakistan Genome Resource compiles biobank data from 173,303 individuals with high familial relatedness, broadening the catalogue of human genetic variation and establishing a population-specific genomic reference for Pakistan.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10648-8 The migration of neurons in developing cerebral and cerebellar cortices is accompanied by massive DNA double-strand breaks due to mechanostress during passage through narrow interstitial spaces.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10643-z Experiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transition to multicellularity in animals.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10679-1 Using single-nucleus multi-omic sequencing, diverse autism spectrum disorder-linked gene mutations converge on transient, stage-specific disruptions in early brain development, and highlight sex-specific gene expression alterations.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10664-8 Permafrost thaw on the Qinghai–Tibet Plateau increases rock-weathering rates while reducing river CO2 emissions, suggesting geological carbon fluxes may eventually outpace thaw-driven emissions.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10650-0 Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradation.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-025-09473-2 Visualization of concentration-driven phase segregation within high-concentration interfacial layers in the context of high-energy lithium–sulfur batteries using liquid-cell electrochemical transmission electron microscopy reveals competitive interfacial reactions under lean electrolyte conditions at different phase boundaries.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-025-09553-3 Fast formation in lithium-ion batteries outperforms conventional slow formation, lowering costs and improving battery capacity, stability and cycle life, offering broader application to electrode systems.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10676-4 A new quantum computer, Quantinuum Helios, which is a 98-qubit trapped-ion quantum processor built on the QCCD architecture, demonstrates performance well beyond classical capabilities and provides a path for scaling up quantum computing.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10657-7 Cryo-electron microscopy and biochemical reconstitution experiments in yeast provide insight into the assembly of the CMGE complex, a helicase that establishes bidirectional DNA replication in eukaryotic cells, and elucidate the role of the firing factor Sld2.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10617-1 A prototype differential atom interferometer operates at the standard quantum limit with no excess noise beyond atom shot noise, achieving performance in line with the specifications for future long-baseline atom interferometers.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10673-7 A miniature three-dimensional optical fibre gripper enables powerful, precise micromanipulation of particles and single cells in confined spaces, bridging the gap between optical and mechanical tweezers.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10638-w A new polaritonic optical method that uses the mid-infrared out-of-plane hyperbolic polaritons mode is described and experimentally validated to allow the examination of picometre-scale interlayer deformations, providing a bridge between nanomechanics and photonics.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10586-5 Analysis of long-term radial velocity data and transit time variations, induced by a super-Earth, a warm Jupiter and a brown dwarf in a coplanar orbit around the relatively young star TOI201.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10614-4 Although Antarctic ice loss projections diverge widely by 2100, this Perspective shows that present-day rates robustly predict mid-century sea level rise, providing a firm basis for near-term planning, while highlighting priorities for model development aimed at resolving longer-term sea level rise uncertainty.
Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10764-5 Towards Conversational AI for Disease Management
Nature, Published online: 17 June 2026; doi:10.1038/d41586-026-01938-2 Report shows region is particularly vulnerable to the effects of climate change.
Nature, Published online: 17 June 2026; doi:10.1038/d41586-026-01719-x Relics of wonder.
Nature, Published online: 17 June 2026; doi:10.1038/d41586-026-01882-1 The European Union has declared that it wants to stop using animals in chemical safety testing. Its goal will need a timeline and a serious funding commitment.
Nature, Published online: 17 June 2026; doi:10.1038/d41586-026-01883-0 Biology has clever ways to mask the effects of potentially harmful gene mutations. Scientists are investigating how this ‘buffering’ works — and how to exploit it.