Structure of the pre-initiation complex explains CMGE biogenesis

Nature

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10657-7
Cryo-electron microscopy and biochemical reconstitution experiments in yeast provide insight into the assembly of the CMGE complex, a helicase that establishes bidirectional DNA replication in eukaryotic cells, and elucidate the role of the firing factor Sld2. ...

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Structure of the pre-initiation complex explains CMGE biogenesis

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