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전체arXiv Math11,266arXiv CS.AI7,894arXiv Physics3,751arXiv Stat1,761PLOS ONE811arXiv Econ535arXiv Q-Bio461eLife163PLOS Global Public Health119PLOS Biology59PLOS Medicine44
arXiv Q-Bio

From Observed Viability to Internal Predictive Approximation: A Single-Subject Latent-Space Analysis of Gait Dynamics Under Occlusal Constraint

arXiv:2605.15862v2 Announce Type: replace-cross Abstract: Understanding adaptive biomechanical systems requires distinguishing observable performance, static multivariate representation, longitudinal displacement, and internal approximation of observed change. This study introduces Level 5, which examines whether the M1-M2 transformation observed in a single-subject gait dataset can be approximated within a selected PCA representation. Gait was recorded with instrumented insoles in a participant with Parkinson's disease under six occlusal observational probes during two sessions eleven weeks apart. A simplified feed-forward neural network was trained to approximate M2 PC1-PC2 coordinates from M1 coordinates, occlusal-probe descriptors, and the longitudinal-transition indicator. In the core analysis aligned with Level 4, the model preserved the Euclidean centroid-displacement hierarchy dOC3 < dONL < dOC2.5. In the extended six-probe analysis, it preserved the broad structure of the exploratory ordering. Held-out M2 and leave-condition-out analyses provided internal tests beyond the full-dataset fit, while a within-session analysis described probe positions relative to ONL. The term predictive is used only in a restricted methodological sense. The model does not provide prospective clinical prediction, patient-level forecasting, or generalization to unseen individuals. Occlusal conditions are treated as observational probes applied during measurement, not as continuous causal drivers of longitudinal evolution. The findings are exploratory, retrospective, representation dependent, and non causal. They do not establish causal occlusal effects, validated viability thresholds, therapeutic superiority, distinct physiological states, or generalizable predictive validity.

arXiv Q-Bio

Observable Performance Does Not Fully Reflect Adaptive System Organization: A Multi-Level Analysis of Gait Dynamics Under Occlusal Constraint

arXiv:2605.00778v2 Announce Type: replace-cross Abstract: In biomechanical systems, observable performance is often used as a proxy for underlying organization, although similar outputs may arise from different adaptive configurations. This study considers the vertical dimension of occlusion (VDO) as a constraint applied to an adaptive neuromechanical system. A single-case design in a patient with Parkinson's disease enabled repeated intra-individual gait observations under six occlusal probes. Three complementary analytical levels were examined: (i) an aggregated scalar score of observable performance, (ii) a conceptual dynamical systems framework, and (iii) an exploratory UMAP representation of 55 standardized biomechanical variables from 270 M1 observations. The revised Level 1 analysis showed that the relative ranking of OC2.5 and OC3 depended on score construction, while their scalar distributions remained close. The Level 3 embedding showed substantial overlap among all six probes and did not identify independently separated condition-specific clusters. OC2.5 and OC3 displayed limited centroid displacement but broad observation-level overlap. The principal result is therefore representational non-identifiability: neither the aggregated score nor the selected low-dimensional embedding uniquely identifies an occlusal-condition-specific system state. VDO is interpreted as a constraint parameter rather than a causal determinant. The findings are exploratory, model dependent, and non causal. They do not establish distinct physiological states, an optimal VDO, clinical thresholds, or diagnostic, predictive, mechanistic, or prescriptive validity.

arXiv Q-Bio

Accelerated MR Elastography Using Learned Neural Network Representation

arXiv:2601.11878v2 Announce Type: replace-cross Abstract: To develop a deep-learning method for achieving fast high-resolution MR elastography from highly undersampled data without the need of high-quality training dataset. We first framed the deep neural network representation as a nonlinear extension of the linear subspace model, then used it to represent and reconstruct MRE image repetitions from undersampled k-space data. The network weights were learned using a multi-level k-space consistent loss. To further enhance reconstruction quality, phase-contrast specific magnitude and phase priors were incorporated, including the similarity of anatomical structures and smoothness of wave-induced harmonic displacement. Experiments were conducted using both 3D gradient-echo spiral and multi-slice spin-echo spiral MRE datasets. Compared to the conventional linear subspace-based approaches, the nonlinear network representation method was able to produce superior image reconstruction with suppressed noise and artifacts from a single in-plane spiral arm per MRE repetition (e.g., 2mm isotropic resolution in 1 min with a total R=10), yielding comparable stiffness estimation to the fully sampled data. This work demonstrated the feasibility of using deep network representations to model and reconstruct MRE images from highly-undersampled data, a nonlinear extension of the subspace-based approaches.

arXiv Q-Bio

Diffusion-Based Quality Control of Medical Image Segmentations across Organs

arXiv:2511.09588v3 Announce Type: replace-cross Abstract: Medical image segmentation using deep learning (DL) has enabled the development of automated analysis pipelines for large-scale population studies. However, state-of-the-art DL methods are prone to hallucinations, which can result in anatomically implausible segmentations. With manual correction impractical at scale, automated quality control (QC) techniques have to address the challenge. While promising, existing QC methods are organ-specific, limiting their generalizability and usability beyond their original intended task. To overcome this limitation, we propose no-new Quality Control (nnQC), a robust QC framework based on a diffusion-generative paradigm that self-adapts to any input organ dataset. Central to nnQC is a novel Team of Experts (ToE) architecture, where two specialized experts independently encode 3D spatial awareness, represented by the relative spatial position of an axial slice, and anatomical information derived from visual features from the original image. A weighted conditional module dynamically combines the pair of independent embeddings, or opinions to condition the sampling mechanism within a diffusion process, enabling the generation of a spatially aware pseudo-ground truth for predicting QC scores. Within its framework, nnQC integrates fingerprint adaptation to ensure adaptability across organs, datasets, and imaging modalities. We evaluated nnQC on seven organs using twelve publicly available datasets. Our results demonstrate that nnQC consistently outperforms state-of-the-art methods across all experiments, including cases where segmentation masks are highly degraded or completely missing, confirming its versatility and effectiveness across different organs.

arXiv Q-Bio

The Emergence of Life in the Light of Evolution

arXiv:2605.05464v3 Announce Type: replace Abstract: The origin of life is often framed primarily as a chemical problem, yet life s defining feature is evolution. Advances in geochemistry, prebiotic chemistry and molecular biology have suggested diverse scenarios for the emergence of genomes, metabolism and cellular compartments on the early Earth, but most of these models ignore the relevance of a population genetics perspective. Here, we argue that origin of life research must expand from asking simply how life began to exploring how it evolved from pre biological systems. Synthesizing evidence from comparative genomics, phylogenetics, biochemistry, and geoscience, we emphasize that the last universal common ancestor (LUCA) was already a complex, ecologically adapted population of cells far removed from the starting point of life, implying a deep, pre LUCA evolutionary history. We highlight how population genetics, ecology, and synthetic biology can constrain origin of life scenarios by making explicit the roles of selection, drift, mutation, horizontal gene transfer, parasites and compartmentalization in shaping early communities. Finally, we outline an evolutionary research agenda spanning proto metabolic autocatalytic networks, protocells, and the emergence of translation and the transition to DNA genomes, such that qualitative models can be formalized through evolution driven hypotheses testable with theory and laboratory experiments, including those with synthetic cells.

arXiv Q-Bio

From IBD tracts to runs of homozygosity: a unified coalescent framework including selection

arXiv:2605.03498v2 Announce Type: replace Abstract: Identity by descent (IBD) tracts and runs of homozygosity (ROH) represent the theoretical and observable sides of chromosomal autozygosity. However, the formal relationship between their length distributions has yet to be established. A coalescent framework is developed here that unifies both concepts within a single analytical formalism, with applications to inferring effective population size (Ne) and detecting selection signatures. Closed-form probability density functions are derived for IBD tract lengths and extended to the observable ROH length distribution by explicitly modelling the displacement of autozygosity boundaries from true recombination breakpoints to the nearest heterozygous flanking marker sites. Mutation, gene conversion, finite marker density, and marker heterozygosity are incorporated as parameters linking IBD tracts to ROH. Background selection introduces a systematic upward bias in apparent tract lengths that requires a generation-dependent Ne that cannot be captured by a single constant value. Selective sweeps produce an asymmetric distortion of the length distribution around a neutral focal site. The sign of this asymmetry indicates the side of the focal site on which the selected locus resides. This directional signal is transient, dissipating quickly after the sweep. In contrast, the signature given by the local Ne reduction persists considerably longer, making the two signatures complementary to determine the age of the sweep. Computational tools are provided to predict tract length distributions under background selection and complete or partial selective sweeps. The application of the theory is illustrated by detecting and localising the selective sweep associated with lactase persistence in European human populations.

arXiv Q-Bio

Working Memory in a Recurrent Spiking Neural Networks With Heterogeneous Synaptic Delays

arXiv:2604.14096v2 Announce Type: replace Abstract: Working memory -- the ability to store and recall precise temporal patterns of neural activity -- remains an open challenge for spiking neural networks (SNNs). We propose a recurrent SNN of $N$ neurons in which each synapse is equipped with $D = 41$ delays, modelled as a weight tensor $\mathbf{W} \in \mathbb{R}^{N \times N \times D}$ and trained end-to-end with surrogate-gradient backpropagation through time. The network stores $M$ arbitrary target spike patterns by representing each as a sequential chain of overlapping Spiking Motifs: contiguous windows of length $D$ that uniquely predict spikes at the next time step. On a synthetic benchmark of $M=16$ patterns ($N=512$ neurons, $T=1000$ steps), training achieves a mean F1 score of $1.0$, with recall emerging first near the clamped initialisation window and propagating forward in time. This result demonstrates that heterogeneous delays provide an efficient substrate for working memory in SNNs, enabling energy-efficient neuromorphic edge deployment.

arXiv Q-Bio

Metric-Topology Factorization: A Computational Framework for Hippocampal-Neocortical Intelligence

arXiv:2603.03362v2 Announce Type: replace Abstract: The brain achieves stability and plasticity in a topologically complex, shifting world through Metric-Topology Factorization (MTF), separating discrete topological indexing for context selection from continuous metric condensation for local inference. Semantically rich environments defy single globally contractive geometries, causing obstructions under shifts, so intelligence factorizes these: the hippocampus provides sparse signatures indexing manifold identity, while the neocortex untangles geometry hierarchically. In the ventral stream, a dynamic-programming-like process quotients symmetries (e.g., translation, scale), transforming non-convex sensory mazes into separable bowls. Offline replay and consolidation amortize transformations for rapid task switching. Dreaming in REM involves stochastic hippocampal traversal to expose and regularize latent structures. Consciousness arises from resolving topological uncertainty into stable embeddings, with awareness for unamortized states. Evolutionarily, transitions like sensorimotor control to language expand topological complexity, demanding advanced indexing-metric separation. Intelligence emerges via recalibrating context-specific geometries, converting global navigation into local dynamics, not deeper search.

arXiv Q-Bio

A Joint Survival Modeling and Therapy Knowledge Graph Framework to Characterize Opioid Use Disorder Trajectories

arXiv:2601.13407v3 Announce Type: replace Abstract: Motivation: Opioid use disorder (OUD) often arises after prescription opioid exposure and follows transitions among onset, remission, and relapse. Linked EHR-survey resources such as the All of Us Research Program enable stage-specific risk modeling and connection to intervention options. Results: We built a multi-stage framework to model time-to-onset, time-to-remission, and time-to-relapse after remission using All of Us EHR and survey data. For each participant we derived longitudinal predictors from clinical conditions and survey concepts, including recent (1/3/12-month) event counts, cumulative exposures, and time since last event. We fit regularized Cox models for each transition and aggregated selection frequencies and hazard ratios to identify a compact set of high-confidence predictors. Pain, mental health, and polysubstance use contributed across stages: chronic pain syndromes, tobacco/nicotine dependence, anxiety and depressive disorders, and cannabis dependence prominently predicted onset and relapse, whereas tobacco dependence during remission and other remission-coded conditions were strongly associated with transition to remission. To support therapeutic prioritization, we constructed a therapy knowledge graph integrating genetic targets, biological pathways, and published evidence to map identified risk factors to candidate treatments in recent OUD studies and clinical guidelines.

arXiv Q-Bio

The rights and wrongs of rescaling in population genetics simulations

arXiv:2601.05367v3 Announce Type: replace Abstract: Computer simulations of complex population genetic models are an essential tool for making sense of the large-scale datasets of multiple genome sequences from a single species that are becoming increasingly available. A widely used approach for reducing computing time is to simulate populations that are much smaller than the natural populations that they are intended to represent, by using parameters such as selection coefficients and mutation rates whose products with the population size correspond to those of the natural populations. This approach has come to be known as rescaling, and is justified by the theory of the genetics of finite populations. Recently, however, there have been criticisms of this practice, which have brought to light situations in which it can lead to erroneous conclusions. This paper reviews the theoretical basis for rescaling, and relates it to current practice in population genetics simulations. It shows that some population genetic statistics are scaleable while others are not. Additionally, it shows that there are likely to be problems with rescaling when simulating large chromosomal regions, due to the non-linear relation between the physical distance between a pair of separate nucleotide sites and the frequency of recombination between them. Other difficulties with rescaling can arise in connection with simulations of selection on complex traits, and with populations that reproduce partly by self-fertilization or asexual reproduction. A number of recommendations are made for good practice in relation to rescaling.

arXiv Q-Bio

Viral population dynamics at the cellular level, considering the replication cycle

arXiv:2510.14481v4 Announce Type: replace Abstract: Viruses are microscopic infectious agents that require a host cell for replication. Viral replication occurs in several stages, and the completion time for each stage varies due to differences in the cellular environment. Thus, the time to complete each stage in viral replication is a random variable. However, no analytic expression exists for the viral population at the cellular level when the completion time for each process constituting viral replication is a random variable. This paper presents a simplified model of viral replication, treating each stage as a renewal process with independently and identically distributed completion times. Using the proposed model, we derive an analytical formula for viral populations at the cellular level, based on viewing viral replication as a birth-death process. The mean viral count is expressed via probability density functions representing the completion time for each step in the replication process. This work validates the results with stochastic simulations. This study provides a new quantitative framework for understanding viral infection dynamics.

arXiv Q-Bio

Artificial Intelligence as an Opportunity for the Science of Consciousness: A Dual-Resolution Framework

arXiv:2509.07001v3 Announce Type: replace Abstract: The encounter of artificial intelligence with consciousness research is often framed as a challenge: could this science determine whether such systems are conscious? We suggest it is equally an opportunity to expand and test the scope of existing theories of consciousness. Current approaches remain polarized. Computational functionalism emphasizes abstract organization, often realized through neural correlates of consciousness, while biological naturalism insists that consciousness is tied to living embodiment. Both positions risk anthropocentrism and limit the possibility of recognizing non-biological forms of subjectivity. To move beyond this impasse, we propose a dual-resolution framework that defines the ontological and epistemic conditions for consciousness. This approach combines the Information Theory of Individuality, which defines the ontological conditions of informational autonomy and self-maintenance, with the Moment-to-Moment theory, which specifies the epistemic conditions of temporal updating and phenomenological unfolding. This integration reframes consciousness as the epistemic expression of individuated systems in substrate-independent informational terms, offering a generalizable theory of consciousness and positioning AI as a promising testbed for its emergence.

arXiv Q-Bio

A computational model of infant sensorimotor exploration in the mobile paradigm

arXiv:2504.17939v2 Announce Type: replace Abstract: We present a computational model of the mechanisms that may determine infant behavior in the "mobile paradigm". This paradigm has been used in developmental psychology to explore how infants learn the sensory effects of their actions. In this paradigm, a mobile (an articulated and movable object hanging above an infant's crib) is connected to one of the infant's limbs, prompting the infant to preferentially move that "connected" limb. This ability to detect a "sensorimotor contingency" is considered to be a foundational cognitive ability in development. To understand how infants learn sensorimotor contingencies, we built a model that attempts to replicate infant behavior. Our model incorporates a neural network, action-outcome prediction, exploration, motor noise, preferred activity level, and biologically inspired motor control. We find that simulations with our model replicate the classic findings in the literature showing preferential movement of the connected limb. An interesting observation is that the model sometimes exhibits a burst of movement after the mobile is disconnected, shedding light on a similar occasional finding in infants. In addition to these general findings, the simulations also replicate data from two recent more detailed studies using a connection with the mobile that was either gradual or all-or-none. A series of ablation studies further shows that the inclusion of mechanisms of action-outcome prediction, exploration, motor noise, and biologically inspired motor control was essential for the model to correctly replicate infant behavior. This suggests that these components are also involved in infant sensorimotor learning.

arXiv Q-Bio

Structural constraints to compare phenomenal experience

arXiv:2502.02154v2 Announce Type: replace Abstract: This article defines a partial order structure to study the relationship between levels and contents of conscious subjective experience in a single mathematical set-up. We understand phenomenal structure as extrapolated relationships among experiences, instead of fixed properties of specific experiences. Our mathematical account is based on multilayer network theory. Multilayer theory is a generalization of graph and network theory, widely used in several scientific domains. This structure is also the underlying conceptual and mathematical structure of most current models of conscious experience. From our simple set of assumptions, yet rigorous analysis, we conclude that assuming the comparison and quantification among phenomenal experiences yield only partial comparison, rather than commonly assumed absolute comparability. This has implications for evolutionary and animal consciousness: evolution may encompass diverse modes of experiencing, not necessarily implying larger ones on an absolute scale. Our characterization elucidates structural constraints on experiential comparisons imposed by assumptions and choices made by modellers as active participants in the scientific process. In summary, in light of our phenomenological intuitions, it might be right that some experiences carry qualitative aspects that make them incompatible or non-comparable with other experiences, quantitatively speaking. Some experiences are comparable (e.g. at some experiential levels), but others are not. These results have direct implications for consciousness science, evolution and animal consciousness.

arXiv Q-Bio

Adapting Evidential Neural Networks to Test-Time Neighbor Fusion Improves Molecular Property Prediction

arXiv:2607.11091v1 Announce Type: cross Abstract: A trained molecular property model can be refined at test time by correcting each prediction with the measured labels of the most similar training molecules, a retraining-free procedure we call neighbor fusion; evidential neural networks make it principled by using their aleatoric and epistemic uncertainty to parameterize a Bayesian update. Our main contribution, PG-EVIKAL, learns a property-distance metric to re-rank structurally similar neighbors by their property relevance before fusion, building on EVIKAL (scalar Kalman filter) and GP-EVIKAL (Gaussian process variant handling correlated neighbors). Evaluated on 16 molecular datasets, PG-EVIKAL reduces RMSE relative to the evidential model baseline on 14 of them, with a median reduction of 19.4%, and improves calibration; in sequential-assay scenarios it further incorporates newly measured molecules, refining predictions as they arrive without retraining. This work demonstrates that evidential uncertainty decomposition is not merely a calibration objective but an actionable inference resource that enables test-time refinement of molecular property predictions.

arXiv Q-Bio

Scaffold splits hide structural-frontier failures in ADMET models

arXiv:2607.10729v1 Announce Type: cross Abstract: Molecular property models are commonly evaluated by holding out Bemis--Murcko scaffolds, yet a scaffold identifier is only one notion of chemical unfamiliarity. We introduce a label-free structural-frontier split that reserves the sparsest and most physicochemically remote scaffold groups, and evaluate it on six public experimental or curated ADMET tasks. Against a 70/10/20 scaffold control with identical acyclic grouping, the frontier inflates equally weighted primary error with a taskwise median of 87.0\% and a skew-sensitive mean of 130.3\% (descriptive task/seed bootstrap interval, 52.1--246.0\%). The mean falls to 75.9\% once BBB is removed; that endpoint is the one whose score ranking inverts at the frontier. A message-passing graph-network control still shows a large gap (mean 82.8\% over four tasks) and does not invert, so a low-capacity head does not explain the effect. We also test Multi-View Frontier Risk Extrapolation (\method), a count-adjusted tail-risk penalty over four molecular views, and treat it as a falsifiable probe. It changes normalized frontier error by only 0.16\% relative to empirical risk minimization for the perceptron head (interval, $-0.43$--0.84\%) and by $-1.9$\% for the graph network; three fixed robust-penalty controls are likewise inconclusive. Against the published Lo-Hi and DataSAIL splitters the frontier inflates error more on average, though no split is uniformly hardest. An audit of 31,561 marine natural products further shows that OOD status and agreement with legacy ADMET predictions depend on the molecular view, endpoint and teacher coverage. Split construction and label provenance are important evaluation constraints in their own right, and the tested training penalties do not resolve the frontier failures we observe.

arXiv Q-Bio

Threat Vectors and the State of the Art in Defense Methods for Security in Neurotechnology

arXiv:2607.10451v1 Announce Type: cross Abstract: Brain-computer interfaces (BCIs) are a class of diverse hardware modalities, associated software, and connected devices which are widely used in a variety of fields, including neurosurgery, biomedical data analysis, and neuroimaging. Recent years have seen rapid advancements in BCI technology, and neurotechnology more broadly, with the first devices now passing clinical trials, early examples of consumer hardware entering the market, and many variants of consumer and medical hardware with increasingly extensive capabilities being developed rapidly. However, research and development in security for BCIs--known as neurosecurity--lags significantly behind the capabilities of BCIs themselves. In an effort to address as many vulnerabilities as feasible immediately, in this paper we review the current state of the art in neurosecurity, thoroughly survey the breadth and complexity of both firmly established and highly probable security threats to BCI systems, and provide recommendations of existing methods from cybersecurity, hardware security, and machine learning which can immediately be applied to address some of these gaps in neurosecurity.

arXiv Q-Bio

Vilya-1: An all-atom foundation model for macrocycle structure prediction and design

arXiv:2607.09998v1 Announce Type: cross Abstract: Macrocyclic peptides are an increasingly important therapeutic modality, but existing computational methods for modeling their structures and properties are limited in scope and do not generalize well across the synthetically accessible chemical space. In this work, we introduce Vilya-1, a deep learning model that addresses two central challenges in macrocycle design: sampling biologically relevant conformations across arbitrary chemistries and predicting key developability properties such as membrane permeability. Vilya-1 operates on a uniform all-atom representation and is trained on heterogeneous structural datasets spanning diverse topologies and chemical classes. Across a broad set of macrocycles composed of canonical and non-canonical residues, Vilya-1 substantially improves geometric accuracy relative to physics-based methods, co-folding networks, and deep-learning conformer generators, while maintaining broad chemical coverage that extends to small molecules. Vilya-1 also supports generative applications, enabling the design of novel macrocycles with tailored chemical, structural, and property profiles. Together, these capabilities establish Vilya-1 as a foundation model for accelerating the development of next-generation macrocycle therapeutics.

arXiv Q-Bio

Life as Plasmas: Autonomy and Interactivism in-materio

arXiv:2607.09747v1 Announce Type: cross Abstract: When is a material system a candidate for life at all? We argue that this question is prior to behavior, functional architecture, or computational capacity, and that at root it is one of physical admissibility. We develop a framework in which minimal autonomy, taken in the interactivist sense of normativity grounded in self-maintaining far-from-equilibrium organization, corresponds to a distinct non-equilibrium phase of matter, and we take complex plasmas, a physical and non-biological system, as its in-materio exemplar. We formalize a diagnostic phase-space whose criteria (sustained free-energy throughput, organizational closure, active information maintenance, and regulated noise sensitivity) constitute necessary conditions for life-attribution. We instantiate the diagnostics across contrasting systems and fix the boundaries of the phase space via B\'enard convection as a driven baseline lacking closure, and a digital self-replicating soup that carries measured informational heredity while its physical closure remains a structural zero. We demonstrate that plasmas satisfy every admissibility condition for minimal physical autonomy while carrying none of the informational heredity that open-ended evolution requires, sharpening the distinction between physical admissibility and biological sufficiency, and bounding downstream questions of machine sentience.

arXiv Q-Bio

A quantitative model for the emergent population dynamics of the melanoma MITF rheostat

arXiv:2607.11820v1 Announce Type: new Abstract: Cancer progression is driven by the ability of cells with identical driver mutations to adopt biologically distinct adaptive phenotypes. Yet the population dynamics implied by intratumour phenotypic heterogeneity is poorly understood. Melanoma, a highly aggressive skin cancer, represents an excellent model to explore phenotype-switching, in part because phenotypic identity is conferred by melanocyte-associated transcription factor (MITF) activity. Here we develop and analyse a multiscale phenotype-structured PDE model for melanoma cell populations in the epidermis, progressing from subcellular MITF dynamics to well-mixed and radially resolved population models. Numerical solutions revealed that the model admits three distinct and stable long-term population behaviours: a slow-growing melanoma of proliferative cells and non-cycling, differentiated cells without invasive potential; a faster-propagating melanoma with an invasive core; and a rapidly growing melanoma with oscillatory core dynamics. More broadly, the analysis also highlights that phenotype reversibility by individual cells does not imply reversibility of phenotype distributions at the population scale. Hence, properties at the single-cell level (e.g., reversibility of invasive capacity) must be extrapolated with caution to populations with coupled cell dynamics. These findings further the understanding of melanoma population dynamics and cell plasticity more generally.

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