Accelerated MR Elastography Using Learned Neural Network Representation

To develop a deep-learning method for achieving fast high-resolution MR elastography from highly undersampled data without the need of high-quality training dataset.

We first framed the deep neural network representation as a nonlinear extension of the linear subspace model, then used it to represent and reconstruct MRE image repetitions from undersampled k-space data.

The network weights were learned using a multi-level k-space consistent loss.

To further enhance reconstruction quality, phase-contrast specific magnitude and phase priors were incorporated, including the similarity of anatomical structures and smoothness of wave-induced harmonic displacement.

Experiments were conducted using both 3D gradient-echo spiral and multi-slice spin-echo spiral MRE datasets.

Compared to the conventional linear subspace-based approaches, the nonlinear network representation method was able to produce superior image reconstruction with suppressed noise and artifacts from a single in-plane spiral arm per MRE repetition (e.g., 2mm isotropic resolution in 1 min with a total R=10), yielding comparable stiffness estimation to the fully sampled data.

This work demonstrated the feasibility of using deep network representations to model and reconstruct MRE images from highly-undersampled data, a nonlinear extension of the subspace-based approaches.