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Review on glioma organoid models proposes new classification framework for brain cancer research

Researchers from the Terasaki Institute for Biomedical Innovation, together with key pioneers in glioma biology, neuro-oncology and stem cell biology, have published a comprehensive review in Society for Neuro-Oncology's journal Neuro-Oncology outlining the evolving landscape of glioma organoid technologies and proposing a foundational classification framework to guide translational brain tumor research.

Medical Xpress

New evidence on graft-versus-host disease prevention in stem cell transplants from unrelated donors

Anti-T-lymphocyte globulin (ATLG) for the prevention of graft-versus-host disease (GvHD) reduces complications and infection-related mortality compared with post-transplant cyclophosphamide (PTCy) in allogeneic hematopoietic stem cell transplantation from unrelated donors. Although PTCy was associated with fewer cases of acute (Grade II–IV) and chronic GvHD, this did not result in a survival benefit for patients with blood cancer. These initial results from the GRAPPA study were presented by DKMS as a late-breaking abstract at the European Hematology Association Congress (EHA 2026) in Stockholm.

NASA Science

Debbie Martínez

In January 2023, Debbie Martínez was selected as deputy director of the Research Services Directorate (RSD) at NASA’s Langley Research Center. She brings more than three decades of experience in aeronautics, project management, and cross‑agency collaboration. Previously, Martínez served as associate project manager for the IASP/Low Boom Flight Demonstrator (LBFD X‑59/Quesst) and AAVP/Commercial Supersonic Technology […] The post Debbie Martínez appeared first on NASA Science.

Medical Xpress

Target with potential to improve CAR T-cell therapy response in patients with blood cancers identified

Researchers at the University of Maryland School of Medicine (UMSOM) have identified a target that may improve the response to CAR T-cell therapy, a treatment for patients with recurrent or difficult-to-treat blood cancers.

Phys.org

Modern human skeletal biology needs to move beyond the strict male/female binary, scientists argue

Human skeletal biologists traditionally provide sex estimations as part of establishing biological profiles (skeletal sex, age-at-death, stature, ancestry/population affinity) for skeletonized remains, often using the shapes and sizes of the pelvis, long bones and skull, among other bones in the body. While analytical methods portray skeletal sex differences as almost purely binary (female or male), a person's sex—including hormones, genetics, external anatomy, internal anatomy and the skeleton—can be more varied than either female or male.

Medical Xpress

Secondhand smoke can leave cancer-causing cadmium in the body

A new study finds that adults who simply breathe in secondhand cigarette smoke have about 1.5 times more of the toxin cadmium in their blood than people in smoke-free environments.

Medical Xpress

Crohn's atlas maps gene shifts across more than 50 gut cell types

A detailed cellular study of Crohn's disease has mapped how gene activity changes across more than 50 cell types in the gut. The study provides an open resource of the genes that characterize each cell type and those whose activity shifts in disease, uncovering new molecular and cellular signatures of immune activity in the gut lining.

Phys.org

Deep Earth model traces 270 million years of seamount formation across oceans

Over 40,000 seamounts—undersea mountains that don't breach the ocean's surface—are scattered across the ocean floor. Some form linear chains, while others occur as dispersed, isolated features that are not part of well-defined volcanic chains.

NASA Science

Lara E. Kearney

Lara E. Kearney serves as the Chief Financial Officer (CFO) of NASA’s Johnson Space Center (JSC). She is responsible for ensuring the overall financial health of JSC, managing the center resources and processes necessary to achieve the Agency’s goals and objectives. Ms. Kearney oversees the center’s financial operations, including budgeting, finance, accounting, business systems, financial […] The post Lara E. Kearney appeared first on NASA Science.

Medical Xpress

How wastewater could spot hidden HIV burden in communities before clinics do

Human immunodeficiency virus 1 (HIV-1) detection in wastewater offers a novel approach to monitor the virus in communities. Baylor College of Medicine researchers and colleagues at collaborating institutions report in Nature Communications that their method, called hybrid-capture genetic sequencing, allows them to analyze viral genomes in detail and specifically identify viral signals coming from community wastewater.

Medical Xpress

The mysterious tooth condition affecting millions of children

Your child's small, delicate, chalk-white baby teeth fall out. In their place grow yellowish-brown, fragile teeth—much to everyone's surprise.

Medical Xpress

Immune activation may determine success of dual-target CAR T therapy in glioblastoma

Dual-target CAR T-cell therapy for recurrent glioblastoma (GBM), delivered directly into the cerebrospinal fluid (CSF), triggers a broad immune response, with natural killer (NK) cell activation linked to better patient outcomes and longer overall survival. CSF of individuals who did not respond to the therapy exhibited a higher proportion of activated regulatory T cells (Tregs) and high baseline levels of immunosuppressive scavenger myeloid cells, according to new research from the Perelman School of Medicine and Abramson Cancer Center at the University of Pennsylvania, published in Cell.

Phys.org

Onboarding support helps merchants adopt digital payment methods

Change can be hard—especially when you're used to receiving change. Switching from cash-based to digital payment methods can be a difficult sell, particularly in developing economies, poorer neighborhoods and among older people who have gotten used to cash. But digital payments have certain advantages for both businesses and consumers, and a Cornell-led research team explored ways to spur adoption of modern payment technology.

Phys.org

Benzene reaction may explain how DNA and RNA building blocks formed on early Earth

Caltech researchers have identified a novel chemical reaction that could explain the formation of the building blocks of DNA and RNA, the molecules that encode all of life's functions. The work is an important step toward understanding how life may have emerged on Earth and potentially elsewhere in the universe, showing the straightforward and efficient pathways through which simple molecules can give rise to complex biological precursors.

Phys.org

Why Arctic sea ice loss could reshape the Gulf Stream's future

The warm Gulf Stream is maintained by coldness. The Barents Sea is a cooling machine. To predict how ocean currents in the Atlantic Ocean may develop, one needs to know what drives them. The hunt for driving forces has led researchers to follow the warm water from the Gulf Stream as far north as it gets.

Medical Xpress

Light switch wakes lung cancer cells up from a protective dormant state

Tumor cells can lapse into a sleep-like state and thereby evade the destructive effect of cancer drugs. In some types of the disease, such as certain forms of lung cancer, this state is triggered by stress hormones in the body. Inside the cancer cells, glucocorticoid receptors recognize the hormones, and the cells respond by lapsing into a state in which they undergo barely any division. This renders many treatments ineffective.

Medical Xpress

Women report poor sleep despite a good night's rest, while men overestimate their own sleep quality

Disturbed sleep is a common problem—and one that has many serious consequences beyond feeling tired the next day. Research has linked insomnia and poor sleep to early mortality and diseases including diabetes and cardiovascular disease.

Phys.org

Being your own boss doesn't always pay off: What 30 years of data reveal

More than 2.6 million Canadians work for themselves, and according to an annual RBC poll conducted in 2025, 59% of Canadians aspire to own a business—the highest level since 2017.

Medical Xpress

Gene therapy prolongs health span and preserves the function of multiple organs in mice during aging

A research team from the Universitat Autònoma de Barcelona (UAB) has shown that a one-time administration of a gene therapy expressing the metabolic factor FGF21 can prolong health span in old mice. The 27-month pharmacology study, published in Molecular Therapy, shows sustained beneficial effects across multiple endpoints associated with aging and health span.

Medical Xpress

Students with highest distress use AI for mental health at elevated rates, study finds

College students have rapidly adopted generative AI, but critical questions remain about its use for mental health support. In a study co-led by investigators at Mass General Brigham, 18% of surveyed college students reported using artificial intelligence (AI) for mental health. Students with more severe mental health symptoms were more likely to do so. The findings are published in the Journal of Affective Disorders.

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