오픈뉴스백과
세계의 오늘한국의 오늘피드
뉴스
전체 뉴스진영별 의제회사정부과학학술용어사전뉴스로 배우기
커뮤니티제보
...

오픈뉴스백과

집단지성 기반 뉴스 검증 플랫폼. 다양한 시각으로 뉴스를 이해합니다.

후원하기

서비스

세계의 오늘한국의 오늘뉴스정부과학학술용어사전소개

법적 고지

개인정보처리방침이용약관콘텐츠 이용 안내

문의

이메일 문의

본 플랫폼에서 제공하는 뉴스 콘텐츠의 저작권은 각 언론사에 있으며, 무단 복제 및 배포를 금지합니다.

RSS 피드를 통해 수집된 콘텐츠는 각 원저작자의 라이선스 조건을 따릅니다. 오픈 라이선스(CC-BY 등) 콘텐츠는 해당 라이선스에 따라 출처를 표기합니다.

오픈뉴스백과는 뉴스 집계 및 검증 플랫폼으로, 개별 기사의 내용에 대한 책임은 해당 언론사에 있습니다.

이용자가 작성한 피드백, 팩트체크, 독자 제보 등의 콘텐츠에 대한 책임은 해당 작성자에게 있습니다.

콘텐츠 제거 요청: contact@opennewspedia.com

© 2026 오픈뉴스백과 (OpenNewsPedia). All rights reserved.

📑

학술

arXiv 등 학술 논문. CC-BY 라이선스로 자유 재사용 가능 — 출처표시 시 상업 사용 OK.

총 453건

분야

전체arXiv CS.AI6,589arXiv Math6,552arXiv Physics2,334arXiv Stat1,126PLOS ONE453arXiv Econ323arXiv Q-Bio318eLife100PLOS Global Public Health90PLOS Biology54PLOS Medicine44
PLOS ONE

The relationships among perceived league product quality, spectator satisfaction, trust, team identification, and loyalty in the Chinese Super League

by Fei Liu, Sisi Wu, Jingyin Zhou, Mu Fan, Fengqin Tian Objective This study integrates perceived league product quality, spectator satisfaction, trust, team identification, and loyalty into a unified analytical framework to examine their relationships, thereby providing empirical evidence to inform more effective marketing strategies for the Chinese Super League (CSL). Methods Guided by the ABC attitude model and conceptual definitions, as well as prior research, the study develops a theoretical model and an initial pool of measurement items. Expert consultation and a pilot study were subsequently conducted to refine items. On-site questionnaires were administered to the CSL spectators, yielding 320 responses, of which 278 were valid. Data were analyzed using SPSS 22.0, AMOS 23.0, and PROCESS v4.2 to assess scale reliability and validity, evaluate the structural model fit, and test path coefficients and mediation effects. Results The theoretical model demonstrated a good fit to data, path analysis revealed that perceived league product quality had significant positive effects on satisfaction (β = 0.759, p p p p > 0.05). Satisfaction (β = 0.038, p > 0.05) and trust (β = 0.029, p > 0.05) did not significantly affect loyalty, whereas team identification had a significant positive effect on loyalty (β = 0.534, p < 0.01). Mediation analysis indicated that the indirect effects of league product quality on loyalty, mediated by satisfaction and trust, were not significant, whereas the indirect effect through team identification was significant. Furthermore, a chain mediation pathway of league product quality → Satisfaction → Team Identification → Loyalty was found to be statistically significant. Conclusion Higher perceived league product quality significantly enhances spectator satisfaction, trust, and team identification. Among these factors, team identification emerges as the strongest predictor of spectator loyalty and serves as the primary mediating mechanism through which perceived league product quality is translated into sustained spectator loyalty.

PLOS ONE

Tree species influence soil carbon quality but not total storage across horizons: European beech on Dystric Cambisol and Norway spruce on Entic Podzol

by Tereza Patrmanová, Andrea Burešová‐Faitová, Václav Tejnecký, Marek Omelka, Ondřej Drábek, Lenka Pavlů, Saven Thai, Jan Kopecký, Markéta Ságová-Marečková Tree species influence below-ground soil chemistry and microbial communities, both of which are key drivers of soil formation. The study compared soils under native European beech and first-generation non-native Norway spruce growing at the same site. Soil under beech was classified as Dystric Cambisol, whereas soil under spruce had developed into Entic Podzol. The objective was to link soil chemical processes with microbial community composition and the resulting quantity and quality of soil organic carbon (SOC) across soil horizons. Soil pH and concentrations of available cations and anions were measured together with dissolved organic carbon (DOC), represented by low-molecular-weight organic acids (LMMOA; ion-exchange chromatography). SOC quantity and functional group composition were characterized using Fourier-transform infrared spectroscopy. Microbial abundance and community composition were assessed by 16S/18S rRNA gene amplicon sequencing and droplet digital PCR. Total carbon contents did not differ between soils, but DOC showed horizon-specific differences, with quinate strongly enriched under spruce. More pronounced differences were observed in carbon quality and its vertical distribution. Elevated concentrations and specific forms of Si, Al, P, and S under spruce indicated progressing podzolization, a process absent under beech. Distinct soil conditions and carbon sources supported contrasting microbial communities. Higher pH and labile carbon availability under beech promoted Pseudomonadota and Bacteroidota, distinguished particularly in the L horizon. In contrast, spruce soils, especially the H horizon were enriched in fungi and metabolically versatile Actinomycetota. Increased abundance of erm resistance genes under spruce also suggested a more competitive microbial environment. Tree species effects on soil properties were detectable throughout the soil profile but weakened with depth. Overall, differences in soil chemistry, microbial communities, and enzymatic activities reflect contrasting decomposition and carbon sequestration pathways, with implications for ecosystem resilience and microbial diversity.

PLOS ONE

Challenges and opportunities for plastic versus mixed waste enterprises in Greater Accra and Kisumu: A qualitative study

by Ruby Hornuvo, Eunice Emefa Boafor, Lorna-Grace Okotto, Joseph Okotto-Okotto, Mawuli Dzodzomenyo, Moses Asamoah, Jim Wright Consumption of products packaged in plastics is growing in Sub-Saharan African cities, whose populations often lack solid waste management (SWM) services. The informal sector often fills gaps in plastic waste collection and recovery that are not met by formal SWM. To reduce plastic waste mismanagement and its associated health risks, SWM systems are needed that separate plastic waste for reuse or recycling. However, little is known about the contributions and challenges facing the mixed formal-informal enterprises in such cities’ SWM chains. This multi-country qualitative study therefore aimed to contrast the specific challenges of plastic waste collectors with those facing general waste collectors. Eleven focus group discussions (FGDs), 6–12 participants per FGD (n = 87 in total), were held with plastic main collectors and sub-collectors (4 FGDs), and general waste collectors (2 FGDs)in Greater Accra, Ghana, and waste sub-collectors (2FGDs), waste intermediaries (2FGDs) and apex plastic traders (1FGD) in Kisumu, Kenya, differentiating business types and plastic from mixed waste enterprises. Barriers, enablers, and solutions were identified through thematic coding and analysis of transcripts. We find differing SWM trajectories in Accra versus Kisumu. Domestic waste separation remains low in Kisumu, whilst Accra’s SWM system evolved from flexible to rigid plastic separation. Mixed and plastic waste collectors reported shared challenges, such as lack of crushing or transport equipment, harassment, greater hazardous faecal matter in waste streams, and lack of societal recognition. Additionally, specialist plastic waste workers in Greater Accra reported business-specific challenges, notably price volatility from seasonally variable plastic waste generation and from bulk international waste plastic imports, alongside theft of separated plastics. Accra’s informal plastic waste sub-collectors were mostly elderly women who reported occupational health challenges from bending and lifting waste. Our findings highlight the need for context-sensitive plastic SWM programmes, including fair bargaining and price regulation measures, occupational health programmes and safer diaper SWM.

PLOS ONE

How work hours affect well-being: A target trial emulation

by Ballerina X. S. Chong, Chris G. Sibley, Joseph A. Bulbulia Studies link longer work hours to multiple dimensions of well-being, but correlations do not show what would happen if hours changed. Target-trial emulation addresses this problem by specifying the experiment we would like to run and then approximating it with observational data. Using three annual waves of the New Zealand Attitudes and Values Study (NZAVS, N = 24,579; 2020–2023), we estimate how 28 well-being outcomes would differ if the same cohort of pre-retirement adults worked 10 more or 10 fewer hours per week than observed. We compare what would happen if weekly hours shifted up by 10 or down by 10 with what actually occurred, after accounting for dropout, using machine-learning methods to adjust for baseline differences. Increasing work hours by 10 most clearly raises fatigue and reduces sleep; body mass index (BMI) and perceived physical health also shift adversely but are more sensitive to residual confounding, while perceived support increases slightly but remains confounding-sensitive. Decreasing work hours by 10 most clearly lowers fatigue; BMI and perceived physical health also shift favourably but are likewise more sensitive to residual confounding. Most outcomes show little movement under either policy, and the downward shift is better supported by the data. Naive baseline associations are broader, larger, and sometimes reversed in sign, whereas sensitivity analyses (E-values) indicate that the clearest fatigue effects are robust to moderately strong residual confounding. Under the stated assumptions, work-hour shifts affect recovery and perceived physical health more than broad well-being.

PLOS ONE

Association of the planetary health diet score with obesity, high blood pressure, dyslipidemia, and cardiometabolic risk markers: Using data from the 2016–2020 Korea National Health and Nutrition Examination Survey

by Ujin Lee, Eugene Kang, Bomi Kim, Diana Shubekova, Adiyasuren Dookhuu, Heejin Lee, Jung Eun Lee, Minji Kang Noncommunicable diseases (NCDs) remain the leading cause of death worldwide, with unhealthy diets and insufficient physical activity as major contributing factors. The Planetary Health Diet is a sustainable dietary pattern linked to chronic diseases, but studies in Asian populations remain limited. Therefore, the aim of this study was to investigate the associations between the Planetary Health Diet score and cardiometabolic risk factors among Korean adults. We used KNHANES 2016–2020 data (n = 25,336), and the Planetary Health Diet score was calculated in accordance with the Lancet Commission guidelines. Participants were categorized into quartiles according to the Planetary Health Diet score, and multivariable logistic regression models were used to examine associations with obesity, hypertension, dyslipidemia, an elevated triglyceride-to-HDL cholesterol ratio, impaired fasting glucose, and an elevated HbA1c level. A higher Planetary Health Diet score was significantly associated with lower odds of hypercholesterolemia in women and was related to reduced prevalence of abdominal obesity, hypertension, low HDL-cholesterolemia, and elevated glycated hemoglobin (HbA1c) depending on age group. No significant associations were observed in men. These findings suggest that higher Planetary Health Diet scores may be associated with selected cardiometabolic markers among Korean women. Further research is warranted to confirm the applicability of the Planetary Health Diet score in Korean dietary contexts.

PLOS ONE

Neuroblastoma cell growth and invasiveness is modulated by the activity of N-acetylglucosaminyltransferase-III

by Adam P. Burch, M. Kristen Hall, Ruth A. Schwalbe The presence of complex N-glycans with β1,6-N-acetylglucosamine (GlcNAc) on cells has long been associated with cancer. For this reason, the role of N-acetylglucosaminyltransferase-III (GnT-III, MGAT3) to hinder terminal N-glycan processing by the addition of β1,4-GlcNAc residues (bisected N-glycan), has earned GnT-III a reputation as a tumor suppressor. In this study, by the creation and characterization of human MGAT3 knockout in the Be(2)-C cell line, a NB cell line, (MGAT3-/-), we solidify GnT-III activity as a suppressor of NB progression by showing that the loss of GnT-III coincided with increased cell proliferation and cell spheroid invasion, along with cell migration, and cell-cell adhesion, and modified cell types. Lectin blotting results indicated that bisected N-glycans were greatly diminished in MGAT3-/-. Further GNL and L-PHA binding suggested that oligomannose and β1,6-GlcNAc branched N-glycans were raised in MGAT3-/- relative to the BE(2)-C cell line. Cellular phenotypes of MGAT3-/- could be rescued by transient expression of Mgat3 cDNA. Likewise, altered levels of bisecting GlcNAc N-glycans in a rat NB cell line (NB_1) overexpressing GnT-III had reduced cell-cell adhesion, cell migration, and cell invasiveness. We conclude that lowered GnT-III activity promotes cell invasiveness and growth in NB, and speculate that oligomannose and β1,6-GlcNAc branched N-glycans are key determinants.

PLOS ONE

Multidrug resistance and inappropriate empiric therapy as predictors of hospital stay in diabetic foot infections

by Lana Zuriegat, Rania Itani, Khawla Abu Hammour, Rana Abu-Farha Objectives This study explored the causative pathogens, resistance patterns, and treatment appropriateness for diabetic foot infections (DFI) at a tertiary care center in Jordan. Methods A retrospective review was conducted on 234 patients diagnosed with DFIs at a tertiary care center in Jordan. Data collected included patient demographics, diabetes history, infection severity, culture results, and antibiotic treatment details. Bacterial isolates were classified as multidrug-resistant (MDR) or non-MDR based on standard definitions. Therapy was considered appropriate if at least one antibiotic given within the first 48 hours of admission covered all identified pathogens and was administered with the correct dosage, formulation, and route. Statistical analyses examined the relationship between resistance patterns, treatment adequacy, and hospital stay duration. Results The most frequently isolated bacterium was Staphylococcus aureus, identified in 117 cases (50.0%), including MRSA (n = 46, 19.6%) and MSSA (n = 71, 30.3%). This was followed by Escherichia coli in 33 cases (14.1%) and Pseudomonas aeruginosa in 32 cases (13.7%). MDR organisms accounted for 152 infections (65%). Empiric therapy was deemed appropriate in 111 patients (47.4%), inappropriate in 74 (31.6%), and not assessable due to missing data in 49 (20.9%). Following culture and susceptibility results, antibiotics in 87 cases (37.2%) remained unchanged. In multivariate analysis, only infection severity was significantly associated with prolonged hospitalization (β = −0.161, P = 0.034). Conclusion MDR organisms were common in DFIs but not significantly associated with prolonged hospitalization. Infection severity was the key predictor of length of stay. These findings highlight the importance of early infection assessment, appropriate empirical therapy based on local resistance patterns, and robust antibiotic stewardship.

PLOS ONE

GS-YOLO: A lightweight high-accuracy model for small target detection in drone aerial images

by Xiaoyuan Jin, Xiyuan Zhu, Dongdong Kang, Wangyu Shen, Yang Zhao, Xun Li, Baoxi Yuan, Yuzhen Zhao For the problems of weak feature representation, significant scale variation, and background interference in small target features of unmanned aerial vehicle (UAV) aerial images, existing detection methods struggle to achieve both lightweight deployment and detection accuracy. Therefore, this paper proposes an extremely lightweight and accurate small target detection architecture named GS-YOLO. Through modular innovation, it achieves extreme lightness and improved detection performance. The core innovations include: 1) Design of a lightweight small target perception attention fusion module C2FGhostLight, using proportionally optimized GhostConv to replace traditional convolution, combined with a dual-path lightweight attention mechanism, which significantly reduces parameters while dynamically suppressing background interference; 2) Proposal of a lightweight channel attention module for small target perception (SOLCA), through a “channel focusing-local enhancement” dual-branch compact structure and adaptive weighted fusion, to strengthen weak feature representation. Experimental results show that on the VisDrone public dataset, GS-YOLO improves mAP50 by 0.9% compared to YOLOv8n, with a model parameter size of only 0.84M. It maintains lightweight characteristics and provides a solution for engineering applications in UAV aerial photography scenarios.

PLOS ONE

Inequalities in referrals to social prescribing from primary care in England: A retrospective observational study

by Efundem Agboraw, Anna Wilding, Luke Munford, Matt Sutton, Paul Wilson Background Social prescribing is a growing community health intervention and has been associated with improved patient outcomes. However, the evidence around inequalities in referrals shows varying patterns. We aim to examine referrals to social prescribing link workers funded by the Additional Roles Reimbursement Scheme in England. Methods We conducted a retrospective observational population-based study, using primary care data from Clinical Practice Research Datalink (CPRD) Aurum from 1st July 2019–31st March 2024. Participants included over 12 million patients aged 16 years or older. We examined the likelihood of offers and subsequent referrals to social prescribing by patient- and area-level characteristics using logistic regression and report odds ratios (ORs). Results Since July 2019, approximately 4% of the CPRD population have been offered a referral to social prescribing. 77·7% of those were referred. Patients who are: female, older, living in less deprived areas and have multiple long-term conditions have higher odds of being offered social prescribing (Female OR = 1·35, 95% CI [1·32 to 1·38] p < 0.001). Factors such as region, rurality, and ethnicity do not result in inequalities in offers compared to the general population. Of those offered, we find that those who are female, those from non-white ethnicities (Black, Asian and Mixed), and have multiple long-term conditions had higher odds of accepting offers of referrals (being referred). Conclusion Referrals to social prescribing have increased following the national rollout of link workers. However, inequalities in offers and referrals to social prescribing have been identified by patient and area-level factors. Our findings indicate that policies should improve awareness of social prescribing in deprived areas and direct certain patient groups, such as ethnic minorities, males and those older to the benefits of being referred to social prescribing.

PLOS ONE

Geoglyphs and formative-period activity in the middle Chillón Valley, Peru: Ceramic association and null-model tests of route proximity

by Christian Mesía-Montenegro, Ángel Sánchez-Borjas Geoglyphs are widespread in arid landscapes, but their chronology and relationship to movement corridors are often difficult to evaluate where direct dating is unavailable. This study examines four geoglyph groups documented through systematic pedestrian survey and RPAS-based recording in two quebradas of the middle Chillón Valley, central coast of Peru: Huarabí (n = 2) and Pichausa (n = 2). Chronological inference is necessarily limited. Diagnostic Formative-period ceramics were recorded only in Huarabí, where they indicate nearby activity rather than directly dating geoglyph construction. Pichausa remains chronologically unresolved. To evaluate whether the documented geoglyphs occur closer to mapped route proxies than expected under explicit counterfactual assumptions, we measured nearest-route distances from within-geoglyph sampling points (k = 20 per geoglyph; n = 80 total) and from six unweighted Formative ceramic findspots in Huarabí. Observed distance distributions were compared with Monte Carlo simulations in which geoglyph shapes were randomly repositioned within defined survey windows while route geometries remained fixed. Across 999 simulations, Huarabí deviates from the tested null model under the survey-polygon window, or buffer = 0 m (p = 0.021), whereas Pichausa does not (p = 0.380). Results vary substantially under broader availability windows, indicating that inference is strongly conditioned by how potential placement space is defined.. These findings provide exploratory, model-dependent evidence that some Huarabí geoglyph contexts and associated ceramic findspots occur nearer to mapped route proxies than expected under the specified null model. They do not establish intentional route association, geoglyph construction age, or valley-wide spatial organization. The principal contribution is methodological: the study demonstrates how small geoglyph datasets can be evaluated through transparent null-model procedures while making explicit the limits imposed by sample size, surface chronology, spatial uncertainty, and the absence of terrain-based feasibility modeling.

PLOS ONE

Leadership education to support person-centred health and social care: A scoping review of empirical literature

by Qarin Lood, Ewa Carlsson Lalloo, Jana Bergholtz, Emmelie Barenfeld The purpose of this scoping review was to map evidence on leadership education to support person-centred care. Specifically, the review aimed to identify the key content of such education, the educational methods used, the reported results, and gaps in the existing literature. The review was conducted using the Joanna Briggs Institute methodology for scoping reviews and reported in accordance with PRISMA-ScR guidelines. Peer-reviewed empirical literature on leadership education for people with leadership roles in health and social were included, without restrictions on publication year or study design. Qualitative, quantitative, and mixed-methods designs were eligible. Educational methods were summarised descriptively, and education content and results were iteratively synthesised and categorised. Methodological quality was not formally assessed, consistent with scoping review methodology. Of 2548 identified records, 22 publications met the eligibility criteria. Leadership education interventions were predominantly conducted in Northern Europe and mainly targeted registered nurses in leadership roles. Educational content commonly addressed leadership theories and styles, person-centredness, and facilitation skills. Educational methods were largely based on longitudinal, work-based learning approaches, and reported results primarily reflected perceived improvements in leadership practices, workplace culture, and care practice outcomes. However, outcomes were largely self-reported, context-specific, and seldom assessed using standardised or comparative measures. Interpretation of the findings is limited by the small number of publications, the predominance of qualitative and non-comparative designs, and the narrow geographical and professional focus of the evidence. These limitations restrict conclusions regarding effectiveness, generalisability, scalability, and sustained system-level impact. Despite these limitations, the findings suggest that leadership education may support leadership practices and care improvement. The review identifies substantial gaps in the global evidence base, highlighting the need for more diverse, theory-informed, and rigorously evaluated leadership education that engages multiple professional groups, incorporates patient and relative perspectives, and examines implementation and transferability across varied health and social care contexts.

PLOS ONE

Detection and genetic characterization of Tembusu virus and other flaviviruses from mosquitoes in Lao PDR

by Chittaphone Vanhnollat, Somsanith Chonephetsarath, Somphavanh Somlor, Veaky Vungkyly, Tiger Soulaphy, Sopha Vongsanga, Irina V. Etobayeva, Thomas Bigot, Gary Wong, Andrew G. Letizia, Paul T. Brey, Philippe Buchy, Khamsing Vongphayloth Background Lao People’s Democratic Republic (Lao PDR), located in Southeast Asia and known for its rich biodiversity, is part of a region recognized as a hotspot for emerging and re-emerging infectious diseases. Among flaviviruses, dengue virus (DENV) and Japanese encephalitis virus (JEV) are recognized public health threats. However, other reemerging mosquito-borne flaviviruses may also infect humans and cause diseases. Despite that, their distribution and public health impact in Lao PDR are not well understood due to limited past surveillance. Methodology Mosquitoes were collected using CDC light traps from 2021 to 2024, as part of vector and pathogen surveillance studies conducted across six provinces. A total of 2,548 female mosquitoes, representing 100 species from 11 genera, were collected and morphologically identified. Of these, 1,622 mosquitoes were pooled into 1,008 “mini pools” according to species and collection site. The pools were screened for flaviviruses by nested RT-PCR. Positive samples were further analysed by metagenomic sequencing, and coding-complete genomes were recovered and subjected to phylogenetic analysis. Primary results We recovered thirteen coding-complete genomes through metagenomic sequencing, which included one Tembusu virus (TMUV) strain (TMUV/Mos_L010) from Culex vishnui mosquitoes and 12 other insect-specific flaviviruses (ISFVs). Phylogenetic analysis placed TMUV/Mos_L010 in cluster 3, closely related to a TMUV strain known to be pathogenic to dolphins in Thailand, with more than >99% bootstrap support for amino acid homogeneity. The detected ISFVs were part of the classical insect-specific flavivirus (cISFV) lineage and were further classified into five subgroups according to their associated mosquito genera: Aedes (1), Anopheles (1), Culex (2), and Uranotaenia (1). Conclusions This study documents the first detection of TMUV in Laotian mosquitoes and extends the known distribution of cluster 3 TMUV strains. The discovery of diverse ISFVs shows the rich and underexplored virome among Laotian mosquito populations. These findings highlight the need for enhanced arbovirus surveillance and ecological research to assess zoonotic risks of spillover infections in Southeast Asia.

PLOS ONE

Bidirectional fusion heterogeneous graph networks for semi-supervised Bitcoin transaction anomaly detection in dynamic transaction graphs

by Bo Xiao, Wei Yin Detecting anomalies in the Bitcoin transaction network is critical for ensuring blockchain security and stability. The network’s heterogeneous structure and dynamic nature, coupled with scarce labeled anomalies, pose significant challenges for traditional graph-based methods. To address these, we propose Bidirectional Fusion Heterogeneous Graph Network (BF-HGN), a semi- dynamic supervised model for Bitcoin transaction anomaly detection task. BF-HGN designs multi-type feature embedding and alignment strategies to effectively unify features across heterogeneous transaction–address nodes. A bidirectional temporal fusion mechanism is proposed to capture long-range temporal dependencies that unidirectional models often miss. To alleviate class imbalance and limited annotations, a Class-balanced Classifier (CBC) combined with Adjacency Adaptation (AA) and Adaptive Feature Space Regulation (AFSR) losses is proposed to generate pseudo-anomalous nodes closely resembling real anomalies, improving discrimination boundaries. Experiments on the Elliptic++ dataset demonstrate that BF-HGN outperforms existing methods, achieving F1 scores of 0.6301 and 0.5784 for transaction and address nodes, respectively, establishing a new benchmark for Bitcoin transaction anomaly detection.

PLOS ONE

Isolation of bioactive compounds from the petroleum ether soluble fraction of <i>Eichhornia crassipes</i> (Mart.) Solms flowers with dual evaluation: <i>In silico</i> studies of isolated molecules and <i>in vitro</i>/<i>in vivo</i> activities of the extract

by Md. Mirazul Islam, Suriya Akter Shompa, Hasin Hasnat, Safaet Alam, Saima Jahan Riti, Ferdousy Kabir, Md. Sakhawat Hossain, Mohammad A. Rashid Eichhornia crassipes (water hyacinth), an invasive aquatic plant, has attracted interest as a potential source of pharmacologically active natural products despite its ecological impact. The present study investigated the petroleum ether soluble fraction (PSF) of the methanolic extract of E. crassipes flowers to identify bioactive constituents and evaluate their biological activities. Chromatographic isolation followed by ¹H NMR spectroscopy led to the identification of five compounds: Kaempferol (Compound 1), Luteolin (Compound 2), Stigmasterol (Compound 3), 4-carboxybenzyl alcohol (Compound 4), and 4-methoxybenzaldehyde (Compound 5). Antimicrobial activity was assessed using disc diffusion and minimum inhibitory concentration (MIC) assays, thrombolytic activity through an in vitro clot lysis method, and antidiarrheal activity using the castor oil–induced diarrhea model in mice. Molecular docking and ADMET analyses were performed to explore potential target interactions and pharmacokinetic characteristics. The PSF exhibited moderate antimicrobial activity, with the highest inhibition against Bacillus subtilis (20.33 ± 1.25 mm) and MIC values ranging from 15.6–500 μL/mL. The extract also produced 14% clot lysis in the thrombolytic assay. In vivo antidiarrheal testing showed dose-dependent inhibition, reaching 38.89% reduction in diarrheal count at 600 mg/kg, approaching the activity of loperamide. Molecular docking analysis revealed that the identified compounds exhibited potential binding affinities comparable to standard ligands, suggesting potential interactions with relevant biological targets. The stigmasterol showing the highest interaction toward the κ-opioid receptor (−10.3 kcal/mol), comparable to loperamide (−9.1 kcal/mol). Flavonoids such as kaempferol and luteolin demonstrated notable binding with antimicrobial targets including dihydrofolate reductase (DHFR) and β-ketoacyl-ACP synthase (KAS), as well as thrombolytic target tissue plasminogen activator (TPA). ADMET predictions indicated favorable drug-likeness for the flavonoids but highlighted lipophilicity-related limitations for stigmasterol. Collectively, these findings highlight the PSF of E. crassipes as a promising reservoir of multi-target phytochemicals with potential applications in gastrointestinal, infectious, and thromboembolic disorders.

PLOS ONE

Higher dietary polyphenol intake is associated with reduced pain sensitivity and migraine-related disability: A cross-sectional analysis

by Gabriele Bertotti, Alberto Roldán-Ruiz, Jaime Rodríguez-Vico, Andrea Gómez-García, Paula Marrero-Fernández, Miguel López-Moreno Introduction Migraine is a highly disabling neurological disorder characterized by recurrent headache attacks and altered pain processing. Emerging evidence suggests that dietary patterns rich in antioxidant compounds may modulate migraine-related pathophysiology, yet the specific association between polyphenol intake and objective pain sensitivity measures remains unclear. This study aimed to examine the association of dietary polyphenol with pain sensitivity and migraine-related disability in individuals with migraine. Materials and methods This cross-sectional study including 72 adults (65 women) with a confirmed migraine diagnosis according to ICHD-III criteria. Participants completed a 3-day dietary record, and polyphenol intake was estimated using the Phenol-Explorer database. Clinical outcomes included pressure pain thresholds (PPTs) at trigeminal and extratrigeminal sites, migraine-related disability (MIDAS), perceived stress (PSS), and handgrip strength. Associations were analyzed using Pearson correlations and multiple linear regression models adjusted for age, sex, BMI, energy intake, and comorbidities. Results Participants with longer disease duration reported higher polyphenol intake (p < 0.05). Total polyphenol intake was positively correlated with PPTs at the masseter (r = 0.27) and middle temporalis (r = 0.31), and inversely correlated with MIDAS scores (r = −0.25, all p < 0.05). In adjusted regression analyses, higher polyphenol intake predicted increased PPTs (masseter: β = 0.33; middle temporalis: β = 0.38) and lower MIDAS scores (β = −0.25, all p < 0.01). No associations were observed with handgrip strength or perceived stress. Conclusions Higher dietary polyphenol intake was associated with reduced pain sensitivity and lower migraine-related disability, suggesting a potential role for polyphenol-rich diets in migraine management. Further randomized controlled trials are needed to confirm these associations and explore the mechanisms through which polyphenol-rich diets may influence migraine-related outcomes.

PLOS ONE

Sprint velocity and step frequency during repeated sprint ability testing are associated with high-intensity locomotor activity in elite female field hockey

by Carlos Rivera, Pablo González-Frutos, Fernando Naclerio, Javier Mallo, Santiago Veiga Field hockey is an intermittent, high-intensity team sport in which global positioning system (GPS) monitoring and field-based fitness testing are widely used; however, the relationship between repeated sprint ability (RSA) determinants and match physical demands remains unclear. This study examined the association between RSA kinematic variables (sprint velocity, step frequency, and step length) and GPS-derived locomotor activity metrics during elite female field hockey matches. Fourteen elite female field hockey players (all members of a first team competing at the highest national and European level) completed a linear RSA protocol consisting of six 30-m maximal sprints interspersed with 30 s of active recovery. External load was quantified during four official competitive matches played against top-level opponents (teams ranked in the top four of the national league or National Cup semi-finalists) within three weeks of testing using 10-Hz GPS devices. RSA sprint-velocity metrics showed very large correlations (r > 0.70, p -¹), high-speed running per minute (HSR·min-¹) and high-intensity accelerations (>3 m·s-2·min ⁻ ¹). Step frequency also demonstrated very large associations (r > 0.70, p -¹, HSR·min-¹, and maximal acceleration, whereas step length was not significantly related to any match variable. These findings indicate that RSA performance, particularly sprint velocity and step frequency, is associated with high-intensity match demands in elite female field hockey. RSA testing may therefore represent a practical, low-cost tool for monitoring or approximating GPS-derived locomotor activity during competitive matches.

PLOS ONE

Using the task-technology fit model to examine the use of telemedicine applications by general practitioners in Indonesia: A qualitative study

by Ni Luh Saddhwi Saraswati Adnyani, Rajesri Govindaraju, Khoirul Muslim, Titah Yudhistira Telemedicine has been recognized for improving healthcare accessibility and cost efficiency. However, telemedicine applications still face several limitations that must be addressed to better support users and their tasks. This study adopted the task-technology fit (TTF) model, encompassing task, technology, TTF, utilization, and performance impact aspects, to qualitatively explore general practitioners’ (GPs) perspectives and experiences regarding the use of telemedicine applications for remote healthcare services. Unlike prior telemedicine and TTF studies that predominantly employ quantitative approaches, this study provides an integrated qualitative examination of physicians’ clinical tasks, corresponding technology requirements, perceived TTF, utilization patterns, and performance impact of telemedicine applications, offering richer insights into real-world telemedicine use from physicians’ perspectives. Semi-structured interviews were conducted with 17 GPs experienced in remote consultations. Data were analyzed using content analysis. The findings show that GPs engage in a wide range of clinical tasks during telemedicine consultations. From a technological perspective, telemedicine applications must meet specific requirements to effectively support each of these tasks. Several critical application requirements were identified, particularly those related to clinical communication, data and service integration, and clinical task support. While telemedicine applications generally support physicians’ clinical tasks and contribute to improved efficiency, effectiveness, service quality, and physician–patient communication, significant gaps remain. This study offers valuable insights for telemedicine providers in designing strategies to optimize telemedicine applications in supporting physicians’ tasks, which in turn may enhance physicians’ utilization of telemedicine and improve their performance. In addition, policymakers and regulators may use the results to establish regulatory guidelines regarding the scope of services and standards for safe and standardized telemedicine practice.

PLOS ONE

Influence of person-organization fit on job satisfaction among pre-service preschool teachers of China: Mediation of teaching self-efficacy and perceived teacher competence

by Lu Xing, Xueqi Wu In China, a growing number of preschool education majors demonstrate reluctance to enter the profession upon graduation, posing a challenge to the sustainable development of the early childhood education workforce. Internships represent a critical period for pre-service teachers to develop their professional identity and capabilities. This study investigates the sustainability of pre-service teacher internships by examining the relationship between person-organization (P-O) fit and teachers’ job satisfaction, specifically focusing on the mediating roles of teaching self-efficacy and teaching competence. A quantitative survey was conducted with 493 pre-service preschool teachers (males 10.5%, females 89.5%) from Changsha Normal University between April and May 2024. Using Structural Equation Modeling (SEM), an integrated model of “values/needs matching → self-efficacy → competency development → teachers’ job satisfaction” was tested. The results indicate that P-O fit has a significant positive association with pre-service teachers’ job satisfaction, teaching self-efficacy, and teaching competence. Furthermore, teaching self-efficacy and teaching competence mediate the relationship between P-O fit and teachers’ job satisfaction, both independently and through a chain mediation effect. These findings suggest that to enhance the sustainability of internships and future retention, higher education institutions and kindergartens should prioritize value alignment and the progressive development of interns’ efficacy and competence.

PLOS ONE

Species diversity and geographical distribution of ticks infesting domestic animals in Bagmati Province, Nepal

by Kamana Thapa, Chet Raj Pathak, Somnath Aryal, Surendra Prasad Kanu Background Ticks are important vectors for bacterial, viral, rickettsial, and protozoal diseases in different animals and humans, especially in tropical countries. Tick-borne pathogens (TBPs) are host and vector-species-specific and depict geographical variations. This study was conducted to determine the diversity of ticks and their geographical distribution among domestic animals. Methodology/Principal Findings Ticks were collected from a total of 210 domestic animals: cattle (n = 30), buffaloes (n = 40), sheep (n = 50), goats (n = 30), and dogs (n = 60), representing Chitwan (Terai), Kathmandu (mid-hill), and Rasuwa (high-hill) of Nepal. The genus and species of ticks were identified using morphological keys under a stereomicroscope. Analysis was performed using MS Excel, and Shannon-Wiener’s and Simpson’s diversity indexes were calculated. A total of 4 genera of hard ticks were observed, representing Rhipicephalus, Haemaphysalis, Dermacentor, and Hyalomma. Among them, Rhipicephalus (Boophilus) microplus (30.42%) was most abundant, followed by Haemaphysalis longicornis (26.74%), Rhipicephalus sanguineus (18.8%), Haemaphysalis sulcata (13.23%), and Rhipicephalus decoloratus (2.86%). Similarly, Haemaphysalis spp. (2.18%), Haemaphysalis leachi (2.05%), Dermacentor sp. (1.36%), Rhipicephalus spp. (1.36%), Hyalomma sp. (0.41%), and Rhipicephalus parva (0.14%). Geographical distribution and tick species diversity were higher in Chitwan. Similarly, species diversity in the case of the host was found to be greater in small ruminants. The result suggested higher tick distribution and diversity among warm tropical regions of Nepal. Conclusions This study investigates the distribution of ticks (Haemaphysalis, Rhipicephalus, Dermacentor, and Hyalomma) in domestic animals across various climatic conditions, identifying the high-risk areas and animal species for tick-borne diseases, including zoonoses. The findings highlight the need for advanced research on tick ecology, epidemiology of TBPs, and the implementation of effective control strategies.

PLOS ONE

Identity and mobility through personal ornaments in Upper Paleolithic cantabrian hunter-gatherer societies: Insights from Llonín cave (Asturias, Spain)

by Daniel Pérez-García de los Salmones, David Cuenca-Solana, Borja González-Rabanal, Ana B. Marín-Arroyo, Elsa Duarte-Matías, Marco de la Rasilla-Vives The use of personal ornaments is considered a milestone in human cognitive evolution and the development of complex behavior. The Cantabrian region in the north of the Iberian Peninsula served as a hub of occupation and intergroup contact throughout the Upper Paleolithic, and acted as a climatic refugium during the Last Glacial Maximum (LGM – 25,000–19,000 years ago), constituting a key region for understanding the social and symbolic structures and interactions of hunter-gatherer groups. This study analyses personal ornaments recovered from the Upper Paleolithic stratigraphical sequence at Llonín Cave (Asturias, Spain), spanning from the Upper Solutrean to the Azilian (c. 21.8–11 kya cal BP), that comprises the regional largest and most diverse assemblage. The combination of taxonomic, biometric, taphonomic, and use-wear analyses reveals rarely documented patterns, such as diachronic shifts in the site’s role as an importer and producer of ornaments, the varying social significance of their use, and the strategies for raw material procurement. Furthermore, the study identifies evidence of coastal-inland interactions, allowing the reconstruction of the complete chaîne opératoire for ornament manufacture. These findings provide a framework for reinterpreting the use of personal ornaments among Paleolithic hunter-gatherer groups, facilitating critical discussions on key dimensions such as mobility and identity.

← 이전7 / 23다음 →