"MEDICINES" · 총 61건
필터 보기현재 지수
50.3
0 = 부정 우세
50 = 중립
100 = 긍정 우세
최근 7일 기준 83,887건을 분석한 결과, 뉴스 심리지수는 50.3(균형)입니다. 긍정 4,290건(5.1%)·중립 77,485건(92.4%)·부정 2,112건(2.5%)이며, 중립 비중이 뚜렷하게 높습니다. 성향 지수는 종합 14.8(중도 균형)입니다.
Everest Medicines (HKEX 1952.HK) announced that it has entered into a commercialization license agreement with ...
Everest Medicines (HKEX 1952.HK) announced that it has entered into an exclusive licensing and collaboration ...
A professor at a prominent Delhi University (DU) college was found dead at her flat in east Delhi’s Vasundhara Enclave on Thursday afternoon, with police suspecting foul play.
The victim, who lived alone in her flat, was found dead with a severe head injury, with both her wrists slit and bruises on her face and body.
현금 325만달러·메멘토 지분 75만달러 수령…"파트너사 성장서 창출되는 가치 공유" 큐라클이 맵틱스와 공동 개발한 망막질환 이중항체 'MT-103'의 글로벌 기술이전 업프론트(선급금)를 수령했다고 5일 밝혔다. 업프론트 규모는 총 800만달러(약 116억원)로, 그 중 큐라클의 몫은 400만달러(약 58억원)다. 큐라클은 현금 325만달러(약 47억원)와 계약 상대방인 메멘토 메디신(Memento Medicines, 이하 메멘토)의 지분 75만달러(약 11억원)를 함께 수령했다. 큐라클은 현금 수령과 함께 메멘토 지분을 확보함으로써 MT-103의 후속 개발 성과뿐 아니라 파트너사의 성장 과정에서 창출되는 가치도 함께 공유할 수 있는 기반을 마련하게 됐다고 설명했다....
Cancer patients in India are facing a critical shortage of life-saving chemotherapy drugs, Cisplatin and Carboplatin, disrupting treatment schedules. Hospitals report dwindling stocks, forcing patients to scramble for supplies. Doctors warn that prolonged unavailability of these essential medicines, with limited alternatives, could negatively impact patient outcomes and survival rates.
Prime Minister Shehbaz Sharif on Thursday affirmed that achieving export-led growth targets was the government’s top priority, directing the National Tariff Commission (NTC) to play an active role in facilitating investors, the Prime Minister’s Office (PMO) said. According to the PMO, Prime Minister Shehbaz chaired a review meeting on overall economic growth and the implementation of the National Tariff Policy 2025-30 on Thursday. Prime Minister Shehbaz emphasised that the “active and transparent performance of the NTC was essential for the promotion of industry, trade and investment in the country”, the PMO added. He directed the NTC to play an active role in facilitating investors and industrialists. According to the PMO, the prime minister said the NTC should be modernised by adopting international best practices and using modern technology, including information technology and artificial intelligence. The PMO further said that the meeting was briefed on the implementation of the National Tariff Policy 2025-30. “The briefing stated that under the policy, tariffs for various sectors would be reduced gradually with the objective of achieving export-oriented economic growth targets,” the PMO said, adding that duties on reefer containers and semi-trailers would be abolished to promote and develop the logistics sector. “The briefing further stated that customs duties on specialised vehicles and machinery were being reduced to support the construction sector.” The PMO stated that customs duties on raw materials, particularly those used in cancer medicines, would also be abolished to facilitate the pharmaceutical sector. Federal Minister for Law and Justice Azam Nazeer Tarar, Federal Minister for Climate Change Musadik Malik, Federal Minister for Economic Affairs Ahad Khan Cheema, Federal Minister for Finance and Revenue Muhammad Aurangzeb, Petroleum Minister Ali Pervaiz Malik, and others attended the meeting.
Deputy Prime Minister Dmitry Chernyshenko noted that Russia supplied 6 tons of substances for the production of medicines to Cuba
The Delhi Gymkhana Club was born in 1913, raised for British officers and the colonial set, and was later inherited by bureaucrats, politicians, and the comfortably connected. None of that pedigree could save it, however, from the law. Last week India told it to vacate the land by June 5. The government read a single clause from the club’s own lease, named a public purpose, and issued the notice. The land returns to the state as do the buildings on it. The club says it will fight the decision in court, and it may. But the order is out and the clock has started. In Pakistan, the Lahore Gymkhana was born in the same year, is grander than Delhi’s and also sits on land worth a king’s ransom. But no notice to vacate has been issued. These are the facts from the government documents that explain why. India has ordered the Delhi Gymkhana Club to vacate its premises by June 5 — Credits: BBC 38 paisas a kanal The Lahore Gymkhana sits on state land ringed by The Mall, Jail Road, and Zafar Ali Road. There is no pricier address in the province. Its 1913 lease stretches back to the Raj, and has been repeatedly extended in 1921, 1960, and, in haste in 1996, five years before its expiry. This time it was extended for 50 years to cover the years 2000 to 2050. The gymkhana estate sprawls over 112 acres and the club holds three kanal and 16 marlas more than the record of rights allows — a tiny trespass that nobody thought to note until now. But that is not all. Inside Lawrence Gardens (Bagh-e-Jinnah), the Gymkhana keeps an exclusive cricket ground on three-and-a-half acres of the Agriculture Department. This was never part of the lease, there is no grant for it and no rent is paid. No paper explains how a public garden was fenced off for a private game. For the main estate, the club pays Rs5000 a year in rent. Not per kanal. In total. That comes to Rs417 a month, or under fifty paisas per kanal, for some of the most valuable earth in Pakistan. How little is Rs5000? Consider it against the government’s upper commercial rate. Total land 1,091 kanals 21,820 marla Market value 1,091 × Rs200 million/kanal Rs218.2 billion Fair annual rent 21,820 marla × Rs200,000/marla Rs4.364 billion The land is worth Rs218 billion so fair rent would be about Rs4.36 billion a year. Under the government’s 2023 policy, clubs can pay a tenth of market rent, but this would still come to Rs400 million a year. The club pays Rs5000. For years, the land’s real value sat behind a nominal colonial rent. It became visible when market figures were placed on the record. The admissions of guilt The club filed its defence with the Assembly admitting the buildings came after the lease, which said the government had to approve construction. Over the decades the club built its clubhouse, golf clubhouse, pool, two guest blocks, health club, administration block, mosque and a café in 2012. The Board of Revenue searched for permissions but none were on record. The club has not even paid its token Rs5,000 rent. The Additional Deputy Commissioner’s office sent a notice, dated 26 August 2020, saying that rent had not bee paid since 2011. Then the money. The club swears no public funds reach it but then lists them in the next breath: Rs2 million from President Zia in 1985, Rs2 million from PM Nawaz Sharif the same year, Rs50 million from CM Pervaiz Elahi in 2006, Rs10 million from CM Shehbaz Sharif in 2014. Four heads of government, four gifts from the public purse, to a private club. And who is the club for? Its rulebook answers. Every civil servant of Grade 18 and above may join for a token fee, and so may every commissioned officer of the armed forces. The other way to become a member is to inherit membership. The capture is not an accident of history. It is written into the founding charter. The roll of ordinary members, meanwhile, the club guards as confidential as if it were a list belonging to a Freemason Lodge. The instinct to maintain secrecy runs deep. When citizens used the Right to Information law to ask for the lease and the donor records, the club refused, and carried its refusal to the Lahore High Court, pleading, without blushing, that as a public limited company it was no “public body” and owed the public nothing. In January 2023, the court dismissed the plea. The land belongs to the state, the judge held. Handing over land worth billions of rupees almost free was an enormous benefit and rent of Rs5,000 a year “cannot be even termed as any rate whatsoever.” The same shrug was then offered to the Assembly when it asked who the club’s members were. Lahore Gymkhana — Credits: Express Tribune Institutionalising the giveaway The Gymkhana is no aberration. It is the template: in May 2023 the state made the template law. That month, a caretaker government in Punjab, an unelected stopgap whose only charge was to hold an election, approved a sweeping new policy. It had no mandate to make long-term land decisions but it made one anyway. On May 10 2023, the Colonies Department opened the door to hand prime state land to gymkhana clubs across the province, and fixed their rent at a tenth of market value. The discount was sewn into the rules. The Board of Revenue reports the harvest. The figure that matters is what the clubs actually pay, after the 90 per cent is shaved away: Rs20,000 an acre a year at Dera Ghazi Khan, Mandi Bahauddin, and Chiniot; Rs50,000 at Vehari, Sahiwal, and Dera Ghazi Khan; Rs60,000 at Kamalpur Syedaan in Attock; Rs100,000 at Saddar Gymkhana, Gujranwala; Rs120,000 at Jhang; Rs140,000 at Jhelum and Gujranwala City. An acre of prime city land, for the price of a secondhand motorcycle, every year. And the final irony: this generous policy, the Board says, does not reach the Lahore Gymkhana, because its lease is older. Elite enclaves on public land The Gymkhana is not the only refuge for the officer class in Lahore. Inside the GOR, that broad expanse of prime central land set aside for officialdom, stands the Punjab Civil Officers Mess on Tollington Road. At GOR’s gate stands the colonial Punjab Club. A short walk off, the Lahore Polo Club keeps its grounds and stables inside the Race Course, public parkland surrendered to horses and a handful of players. An exclusive school for the male heirs of the elite, Aitchison College (Chief’s College), spreads over 200 acres. None of these entities bought their land. It is public land, held in trust, enjoyed by the few. Islamabad tells the same story more starkly. The Islamabad Club, sprawled across 352 acres of CDA land, pays about three rupees an acre a month as its gates remain closed to ordinary citizens. The Gun and Country Club rose up on land meant for the Pakistan Sports Board; the Supreme Court declared it illegal in 2018 and ordered the land to be taken back, yet years later auditors could not trace some 38 acres, and the club sat on roughly 37 with no deed, no lease, no licence at all. The court said it aloud: there was no land in Islamabad for a public hospital [for the poor], but there was land aplenty for clubs for the rich. And the hunger has not eased. In Multan, the district administration moves to slice 15 acres off the Central Cotton Research Institute, founded in 1970, the cradle of more than forty cotton varieties, including the region’s first virus-free strain, to feed another gymkhana, while the country’s cotton reserves sit at a record low and we spend hard currency importing the very crop the institute exists to improve. The Pakistan Business Forum has written to the chief minister to stop it. The clubs took the parks. Now they reach into the seed bank. There has been an attempt to quantify this. In 2021, the UNDP put a number on the privileges captured by Pakistan’s elite. Cheap land and capital, tax breaks and soft inputs came to about $17.4 billion a year, which is nearly 6pc of the whole economy. The Gymkhana is merely a place where one may stand and watch the transfer happen: a 112 acres, for Rs5000. When the same hands value, grant, and enjoy the land This mechanism endures not through sloth but through strategy, as the actors make clear. The land belongs to the state. The men who grant it are senior civil servants in the Colonies Department, the Board of Revenue, the office of the Deputy Commissioner. The men who set the value of the land, and thus decide the rent, are with the same revenue service. And the men who enjoy the clubs are, by rule, civil servants of Grade 18 and above and senior officers of the armed forces. The same hands own the land, price the land, rent it, and carry the membership cards. When one cadre handles every aspect of a deal, its low price is no blunder. It is the purpose. No one at that table has any interest in making public land fetch a public price, for all of them gain from the opposite. The officer who would raise the rent, enforce the breach, or cancel the lease must act against his service, his colleagues, and likely his own leisure. That is what makes Sohaib Butt’s report so rare, and so telling. It took a man willing to go against the grain of his service to do the simplest thing: write down what the land is worth. This is the truth worth stating plainly. In Pakistan, real power does not change hands at the ballot box. Governments arrive and depart; the bureaucracy and elites abide. And on the matter of state land for clubs, those who never leave office and those who enjoy the clubs are one and the same. That is why such a file scarcely moves. And it is why it matters so greatly who, in the end, forced it into the open. Nestled within the Bagh-e-Jinnah, is one of the most picturesque cricket arenas of the world — Credits: Dawn archives Two-tiered justice The state can, of course, move on land with great speed if it wants. Take Islamabad, the capital that prides itself on order. For three months its bulldozers have flattened katchi abadis or the informal colonies where the city’s gardeners and nannies, washerwomen and labourers have lived for a generation. Around 25,000 people were driven out of Mulism Colony in Bari Imam alone. Settlements a quarter-century old, Rimsha Colony in H-9 and the largely Christian Allama Iqbal Colony in G-7, were marked for the same fate, along with the ancient villages of Saidpur and Nurpur Shahan.The state’s housing policy counts 60 such settlements in the city, home to between 300,000 and half a million souls; the CDA recognises barely 10 as lawful and brands the rest squatters. And here is the part that should silence the room: a Supreme Court order from 2015 was passed after the merciless clearance of the I-11 settlement left 25,000 people homeless. It stayed the summary evictions altogether. The bulldozers came regardless. The same legal system that cannot dislodge an unpaid colonial lease in 18 months had no trouble dislodging the poor in open defiance of its highest court. Punjab is no kinder about informality. It is just quieter about it. For three decades, it has promised to regularise its katchi abadis, and for three decades that promise has mostly stayed on paper. There is a law to sanction the work done and an agency to get it done but the number of settlements grows faster than the lists of “regularised” ones. Surveys are started and abandoned. Notifications are issued and forgotten. The poor who put up their housing on the edges of Lahore and Faisalabad and Rawalpindi live out their years in limbo, always one bureaucrat’s signature away from eviction. Three decades is a lifetime. A child born in one of these colonies has grown, married, and had children, and the family still cannot say for certain that the ground beneath their feet is legally theirs. Meanwhile, the new law enforcer is punishing and swift. The Punjab government created the Punjab Enforcement and Regulatory Authority (PERA), to clear what it deemed to be encroachments. It is aided by deputy and assistant commissioners and a uniformed force with black Vigos. Through 2025 PERA hired thousands of staff and opened stations across Lahore and beyond, as its drives targeted the small folk. Traders protested its methods: a shop photographed in the evening, sealed the next morning, fined Rs10,000 to Rs25,000, kept shut until the owner paid. Thella wallahs, vendors, kiosks punished for setting up on a footpath. But 112 acres of the city’s finest land, held on a dead lease, built over without leave, exempted by a rule the board invented, is “legitimate possession,” defended for generations. The bulldozer works swiftly for the weak but stalls for the strong. What Rs218 billion could buy instead of membership It is worth listing what Rs218 billion would buy in a place that cannot pay for medicine. In 2025-26, Punjab set aside Rs630.5 billion for its health sector, and proudly announced that for the first time this included Rs79.5 billion for free medicine. And yet Dawn reported that Rawalpindi’s three public hospitals (Holy Family, Benazir Bhutto, and the Teaching Hospital) were given a fraction of Rs4.5 billion they asked for. Their vendors are refusing to deliver stocks until the bills are cleared. The Lahore Gymkhana land, on the other hand, is worth Rs218 billion, or three times the free medicine funding. A single elite golf-and-dining estate, that pays Rs5000 in rent, is worth more than the tab for medicines in a province of 120 million people. The Assembly did its job It took an elected Assembly more than one attempt to set this right. The matter was brought up at the last session but did not move ahead for “mysterious” reasons. The House pressed further. A member moved an adjournment motion and the Speaker called it out: this was elite capture of state land. The Speaker formed a committee and for the first time in history, opened its hearings to the public and TV cameras. The House’s members killed it at the first sitting by placing on the record, all of them, that they sought no membership of the club, only the public interest. In a few weeks they ferreted out from their government two documents that settled everything. The first was the valuation, ADC(R) report (shown above), which turned Rs5,000 into a scandal by comparison. The second document ended the argument. The Law and Parliamentary Affairs Department gave a clean opinion on what the state may do: Clause 6 of the 1996 lease lets the government end the lease at any time, on six months’ notice. Clause 8 says that when it ends, the club is owed nothing for any building it raised. The Board of Revenue added that the state is bound to resume the land when public purpose requires it, or when the lease is broken. India reclaimed its gymkhana land by reading one clause of a lease. Punjab’s lawyers have now confirmed the province holds the same power to take back the Rs218 billion estate, with every building on it, on six months’ notice, and pay nothing. Credit for this denouement goes to the House of elected representatives. What they cannot do alone is sign the order. That pen rests with the executive, which is the same bureaucracy that would rather keep the file shut. Inside Lahore Gymkhana Cricket Museum, the first of its kind in Pakistan — Credits: Dawn archives Options The remedy is not exotic. The simplest one is to cancel the lease. The second option is to take back the land for public use, which is what Delhi did. We don’t need to look far to find precedent. When the Royal Palm Club in Lahore defaulted on its lease of Railways land, the state took the land back and pulled down structures. Indeed, members on both benches have said if it can be done to a club on railway land in Lahore, it can be done to a club on nazul (state) land in Lahore. The most durable option is a legal statute to dedicate the gymkhana estate to a fixed public use. And one use should unite the benches. The estate is a manicured, thirsty green in one of the most poisoned cities on earth. Take it back. Grow a native forest on it the fast and thick Miyawaki way and plan a park. Such greenery traps the dust, cools the air, and pushes back against the smog that sends people to our hospitals each winter. A golf course serves a hundred men. A forest would serve millions. We say the law protects everyone alike but we must admit it does not. The thella wallah is presumed to be illegal and is not given time to prove otherwise. The Lahore Gymkhana Club is presumed to be lawful no matter what the file says. Delhi has shown us the way. There was never a question of what the law allowed if elite land had to be taken back. The Assembly has proven this twice and put proof on record. What remains is the will to choose a public forest or park over a private fairway, the many over the few, the medicine over the membership. The House has spoken. The executive has not. For now, the silence belongs to the people holding the pen, and everyone can see why they would rather not sign.
Most adult Americans take at least one prescription drug, and for too many, getting that prescription filled means battling the very system that’s supposed to help them. Insurance denials have become alarmingly routine. A recent study found that 70% of commercially insured patients face initial claim rejections for new branded medicines. And even when patients […]
The Supreme Court will soon decide a case that could upend the balance built into a bipartisan law that has accelerated the launch of generic drugs and saved American patients, employers, and taxpayers trillions of dollars in recent decades — while still incentivizing biopharmaceutical companies to research and develop medicines in the first place. The […]
The federal cabinet has approved the nationwide implementation of a Track and Trace system for pharmaceutical products across Pakistan, Minister for Health Mustafa Kamal announced on Tuesday. According to an official handout, the system aims to strengthen public health and safeguard citizens from counterfeit medicines. The cabinet has also approved the necessary amendments to the Drug Labeling and Packing Rules, enabling the introduction of “a modern digital system for tracking and verifying medicines throughout the supply chain”, the statement said. “This decision marks a major and historic step towards eliminating counterfeit, fake and substandard medicines from Pakistan,” said Kamal according to the statement. “For the first time, every medicine in the country will be digitally traceable and verifiable, ensuring greater transparency, safety, and accountability,” he said. The statement noted that under the new regulatory framework, all pharmaceutical manufacturers and importers will be required to place standardised 2D barcodes and serialisation data on medicine packaging. The system will enable regulators to monitor medicines from production to consumption, helping to identify and eliminate counterfeit products from the market, it said. The health minister stated that once the system was implemented, consumers would be able to access authentic information regarding a medicine’s expiry date, price and verification status. This would empower them to make informed healthcare decisions and enhance public trust in the pharmaceutical sector, according to Kamal. The Drug Regulatory Authority of Pakistan (Drap) will oversee the nationwide rollout of the system. It will also issue detailed technical guidelines to facilitate the pharmaceutical industry’s compliance, the statement said. “Consultative meetings with relevant stakeholders have already been conducted to ensure a smooth transition,” it added. Kamal emphasised that the initiative would “significantly strengthen the security and quality of Pakistan’s pharmaceutical supply chain”, replacing conventional monitoring mechanisms with a modern digital framework. He highlighted that the adoption of advanced technology would position Pakistan among the leading countries in the region in pharmaceutical regulation and oversight. “The track and trace system will establish a strong and effective barrier against counterfeit medicines and ensure the protection of public health, lives and trust,” the press release quoted the minister as saying.
The Indonesian Food and Drug Authority (BPOM) has called for greater support for standardized herbal medicines, as the ...
Representational image of different medicine pills seen in their original packaging in Brussels, Belgium August 9, 2019. — ReutersConsumers can verify expiry dates, price information.Drug makers must add 2D barcodes on medicine packs.Serialisation data to be mandatory on all...
Um comprimido que conseguiu o ‘impossível’ Chicago, 1º de junho de 2026. A sessão plenária da American Society of Clinical Oncology —o maior e mais influente congresso de oncologia clínica do planeta— não costuma ser lugar de emoção fácil. Os médicos e pesquisadores que lotam o auditório são treinados para a frieza dos dados, para o ceticismo metodológico, para a cautela diante de qualquer resultado que pareça bom demais. Quando os números do estudo RASolute 302 apareceram na tela, a plateia se levantou. Aplausos de pé são raros em congressos científicos. Neste, pareciam inevitáveis. O daraxonrasib não chegou à ASCO como novidade absoluta. Em abril, a empresa americana Revolution Medicines havia divulgado os primeiros resultados: um comprimido tomado uma vez ao dia havia quase dobrado a sobrevida de pacientes com câncer de pâncreas metastático sem resposta à quimioterapia. O g1 contou essa história. Mas dados preliminares, divulgados por uma empresa com interesse financeiro direto no resultado, ainda não são a última palavra da ciência. A última palavra é a fase 3. E foi ela que chegou a Chicago. Daraxonrasib é um antineoplásico oral Adobestock Um novo padrão foi estabelecido O estudo RASolute 302 seguiu o padrão mais rigoroso da medicina: um ensaio clínico randomizado de fase 3. Quinhentos pacientes foram divididos por sorteio em dois grupos —nem os médicos nem os pacientes escolheram quem receberia o quê. Um grupo tomou o comprimido; o outro seguiu com a quimioterapia convencional. Esse formato existe para eliminar vieses e garantir que qualquer diferença nos resultados seja atribuível ao tratamento, não ao acaso. É o tipo de evidência que a medicina exige antes de mudar um protocolo global. Os resultados foram considerados finais —não há análise pendente, não há dado faltando. Os números: No grupo de pacientes com a mutação RAS G12 —a mais comum no câncer de pâncreas—, a sobrevida mediana foi de 13,2 meses com o comprimido contra 6,6 meses com a quimioterapia. Sobrevida mediana significa que metade dos pacientes viveu mais do que isso —e metade, menos. O risco de morte caiu 60%. O tempo até a doença voltar a avançar também dobrou: 7,3 meses contra 3,5 meses com a quimioterapia. Os resultados foram praticamente idênticos quando se analisou o grupo total de pacientes, incluindo aqueles sem mutação RAS identificada. E mais de 31% dos pacientes que tomaram o comprimido tiveram redução mensurável do tumor —contra 11,2% no grupo de quimioterapia. Um dado, particularmente, chamou atenção dos pesquisadores: apenas 1,2% dos pacientes que usaram daraxonrasib precisaram interromper o tratamento por efeitos colaterais. No grupo de quimioterapia, essa taxa foi de 11,2%. A conclusão dos pesquisadores, publicada no Journal of Clinical Oncology, foi direta: o daraxonrasib deve se tornar o novo padrão de tratamento para pacientes com câncer de pâncreas metastático em segunda linha. ‘O aplauso em pé foi merecido’ Stephen Stefani, oncologista da Americas Health Foundation, estava presente na sessão plenária em Chicago. Ao g1, ele explica a comoção: "Raramente celebramos um medicamento com esse perfil: baixa toxicidade, impacto real em sobrevida e um mecanismo inédito para essa doença", diz ele. "Eram mais de 500 pacientes com câncer de pâncreas avançado, já sem resposta à quimioterapia, avaliados no desenho mais rigoroso da pesquisa clínica —e com sobrevida dobrada em relação ao padrão anterior. O aplauso em pé foi merecido." Stefani destaca o peso estatístico dos resultados: "Os 13 meses são uma mediana —há pacientes que viveram muito além disso. Mais de 30% tiveram redução objetiva da doença, com duração suficiente para ampliar a sobrevida de forma significativa. E o perfil de toxicidade é manejável, o que, numa doença dessa gravidade, não é um detalhe menor." Para ele, o resultado ultrapassa o dado clínico. "O resultado confirma que estamos avançando numa direção que por muito tempo pareceu fechada —a de oferecer sobrevida real a pacientes para os quais, até agora, pouco havia a fazer." Por que é tão difícil tratar Para quem não acompanhou a história desde o começo, vale entender o tamanho do obstáculo que o daraxonrasib superou. O câncer de pâncreas mata de um jeito particular. Não avisa. Não dá sintomas no começo. Quando é diagnosticado, cerca de 80% dos casos já estão em estágio avançado ou metastático —espalhado para outros órgãos, fora do alcance de cirurgia. Nos Estados Unidos, aproximadamente 60 mil pessoas recebem o diagnóstico por ano; 50 mil morrem. No Brasil, são 13 mil novos diagnósticos anuais; cerca de 12 mil morrem. A sobrevida em cinco anos, para a forma metastática, é de cerca de 3%. Uma das mais baixas entre todos os cânceres. A resistência da doença ao tratamento está, em grande parte, numa proteína chamada RAS —um interruptor celular que, quando mutado, trava na posição "ligado" e não para de ordenar às células que cresçam e invadam. Isso acontece em mais de 90% dos tumores pancreáticos. Durante décadas, pesquisadores tentaram bloquear o RAS. E falharam. A molécula não oferece uma superfície clara onde uma droga possa se fixar —como uma fechadura cujo miolo foi polido até perder os relevos. A chave entra, mas não encontra onde se firmar. O RAS ficou conhecido na literatura médica como undruggable: intratável. O daraxonrasib conseguiu chegar lá, e não apenas numa variante da mutação, mas em várias ao mesmo tempo. Para os pacientes do estudo, todos metastáticos e sem mais opções após a quimioterapia, isso fez uma diferença de 6,5 meses a mais de vida, em mediana. FDA deve aprovar num futuro breve O próximo passo é a aprovação regulatória. A Revolution Medicines, farmacêutica responsável pelo remédio, confirmou que submeterá os dados à Agência de Alimentos e Medicamentos dos Estados Unidos (FDA) como parte de um pedido formal. A droga já havia recebido o status de Breakthrough Therapy —uma classificação reservada a medicamentos que demonstram vantagem substancial sobre os tratamentos existentes e que garante análise prioritária—, além de designação de medicamento órfão e seleção para o programa National Priority Voucher, que acelera ainda mais a revisão. O acesso compassional, para casos selecionados sem outras opções, já está autorizado nos Estados Unidos. Para o Brasil, o horizonte é mais distante. A Agência Nacional de Vigilância Sanitária (Anvisa) precisaria conduzir seu próprio processo de aprovação. No sistema privado, a Agência Nacional de Saúde Suplementar (ANS) teria ainda que publicar uma diretriz de utilização técnica para que os planos de saúde fossem obrigados a cobrir o medicamento. No sistema público, o obstáculo é financeiro de partida: o valor pago para tratar um paciente com câncer de pâncreas é de cerca de R$ 1.986, enquanto drogas oncológicas novas custam em média dez mil dólares por mês no mercado americano. Não há previsão concreta de quando (nem se) esse acesso chegará ao Brasil no curto prazo. "O resultado confirma que estamos avançando numa direção que por muito tempo pareceu fechada: a de oferecer ganho real em sobrevida a pacientes que, até agora, tinham poucas alternativas”, conclui Stefani.
MANILA, Philippines — A House bill seeking to exempt all essential medicines from the 12-percent value-added tax (VAT) was filed on Monday to “lessen the burden” on Filipinos and help government comply with its responsibility to protect and promote people’s right to health. House Bill No. 9564, filed by ACT Rep. Antonio Tinio, Gabriela Women’s
More than 1 in 10 U.S. adults is currently taking a GLP-1 weight-loss drug. And these medicines are getting cheaper seemingly by the day. Since Wegovy launched, its list price has fallen from roughly $1,300 per month to between $300 and $500 per month. Similarly, Zepbound was once about $1,000 per month, but it now […]
As the conflict destroys local production, Sudanese patients are forced to rely on expensive, smuggled medicines.
[spotlight] HIV treatment has been improved and simplified significantly over the years yet a small fraction of people living with HIV still take complex multi-pill regimens. Spotlight reports on a new combination pill that could make life easier for some in this group. But as two leading experts point out, the development comes against a backdrop where the traditional categorisation of HIV medicines is dissolving.
[Namibian] The Namibian public and the local pharmaceutical fraternity should be encouraged by president Netumbo Nandi-Ndaitwah's recent visit to Fabupharm amid the ongoing shortage of medicines in public hospitals and clinics.