Aneuploidy selects for the acquisition of driver genes in breast cancer

Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10752-9
Screening of chromosome arm-level aneuploidies uncovers that these alterations select for specific basal-like breast cancer driver genes, including PLGRKT, an oncogene whose tumour-promoting activity is associated with highly stress-resistant mitochondria and enhanced detoxification of reactive oxygen species. ...