Breast cancer driver genes found by screening chromosome aberrations<i> in vivo</i>

Nature, Published online: 08 July 2026; doi:10.1038/d41586-026-02014-5
Cancer genomes are unstable, often experiencing gains or losses of whole chromosomes or chromosome arms — changes known as aneuploidies. Experiments in mouse models of breast cancer reveal that these instabilities harbour one or two prevalent genes that drive cancer and that bypass the need to accumulate aneuploidies; they also require an intact microenvironment to produce their effects. ...