Restoring cortical disinhibition improves Huntington’s disease phenotypes

Nature

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Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10671-9
In a mouse model of Huntington’s disease, targeted modulation of neuronal activity restores network function and improves motor deficits. ...

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Neurobiologists improve symptoms of Huntington's disease with targeted brain stimulation in mice

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Restoring cortical disinhibition improves Huntington’s disease phenotypes

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