Oxalate buildup triggers systemic inflammation and cardiac damage, study shows

People with chronic kidney disease (CKD) have a significantly increased risk of death from cardiovascular disease.

They also suffer from chronic inflammation, the causes of which are still only partly understood.

Oxalic acid (oxalate) has so far been known primarily for its role in the formation of kidney stones.

The molecule is a natural metabolic byproduct, is found in certain foods and is normally excreted by the kidneys in urine.

However, when kidney function is impaired, oxalate accumulates in the body and can promote inflammatory processes. ...