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Ahead of possible Cabinet reshuffle, community representatives back their leaders for top posts

The pain principle

A new Rafael Nadal documentary shows us an old, now unpopular way of building a legacy — powering through suffering and impossible odds

Army Chief Says ‘Operation Sindoor’ Ongoing, Signals Readiness For Future Contingencies

Army Chief General Upendra Dwivedi says Operation Sindoor continues with a temporary halt in fighting and forces prepare for possible Operation Sindoor 2.0.

5 Major Developments To Watch Out For On May 30: Karnataka CLP Meet, Potential US-Iran Deal & More

Karnataka Congress CLP meets to pick DK Shivakumar as new CM, US Iran talks near possible deal, Myanmar President U Min Aung Hlaing visits India, Arsenal face PSG in UCL final

RBI warns West Asia war may hit India growth

Mumbai: A prolonged West Asia conflict represents a key downside risk to India's economic outlook according to the Reserve Bank of India (RBI), even as it projected a lower real gross domestic product (GDP) growth of 6.9% for 2026-27 in its annual report compared with 7.6% estimated for the previous financial year.The central bank said the impact of the conflict is likely to remain contained in the near term but warned that an escalation could derail India's otherwise positive growth trajectory."Going forward, India's growth outlook remains positive, though the West Asia conflict and the attendant risks of elevated energy prices, supply chain disruptions, financial market volatility, uncertainty surrounding global trade policies and weather-related disruptions could pose headwinds to growth and inflation in the short run," the Reserve Bank said.Also Read: Iran war - PSBs asked to stay preparedPositive Macro OutlookIt listed healthy corporate and bank balance sheets, government's continued thrust on capital expenditure and the implementation of trade agreements with key partners as positives to help sustain investment and growth momentum."Nevertheless, in a highly uncertain global environment, continuous assessment of the evolving developments is warranted to frame the appropriate policy response on an ongoing basis," the report said.131398139The central bank said that although portfolio flows exhibited a net outflow in 2025-26, strong buffers in the form of ample foreign exchange reserves and modest external debt liabilities continue to impart strength to the external sector, contributing to overall macroeconomic and financial stability.Adequate food grain stocks, sufficient reservoir levels and stable agricultural prospects despite possible El Nino conditions and above-normal summer temperature will keep inflation aligned to the target in 2026-27, according to the RBI. However, upside risks may emanate from a surge in global fuel and commodity prices amid geopolitical tensions, potential spillovers to input and wage costs and volatility in exchange rates.Also Read: India-US trade pact may be weeks away - US Ambassador to India Sergio GorThe central bank projected consumer price inflation for 2026-27 at 4.6%, with risks tilted to the upside, significantly higher than its revised estimate of 3.7% for the previous fiscal.Pressure on BondsDomestic bond yields could face upward pressure if the global monetary easing cycle stalls or reverses in response to persistent oil price shocks amid fragile conditions in West Asia, it said.Geopolitical risk has re-emerged as the dominant drag on global growth in 2026, according to the RBI. "In IMF's baseline scenario, the global economy is projected to grow by 3.1% in 2026 (as against the earlier projection of 3.3% in January), while global merchandise and services trade volume is expected to decelerate to 2.8% in 2026. Further intensification of the conflict, its prolongation or widening geographical spread, if any, remain the key downside risks to the global economic outlook," the report said."However, the government's commitment to fiscal consolidation, along with the liquidity injection measures by the Reserve Bank, is expected to contain the upward pressure on yields. Equity market dynamics would be conditioned by evolving geopolitical developments, global financial market volatility and foreign portfolio investment flows; a deterioration in risk sentiment alongside strengthening of the US dollar could trigger capital outflows," said the RBI's annual report. "At the same time, ongoing efforts to expand local currency settlement framework are expected to further advance rupee based cross-border transactions."

Molecule glue drugs shake up cancer care

One of the biggest advances in pancreatic cancer in decades came out of a crazy idea born in a Harvard University lab.Chemical biologist Gregory Verdine believed you could fight disease-causing proteins hidden inside cells by chemically gluing them to something else in the body and smothering them."Everybody told us this is crazy, that it would never work," he recalls.Revolution Medicines, which bought one of Verdine's companies in 2018, recently announced that one of its drugs doubled the typical survival time for patients with aggressive forms of the disease, from 6.7 months to 13.2 months. The full results from the company's final-stage trial are expected to be the star of the show at the annual confab of cancer doctors in Chicago this weekend.Spurred by the success of RevMed, numerous companies are now racing to develop similar drugs, dubbed "molecular glues", which can be used to treat a variety of ailments. And investors and pharmaceutical companies with deep pockets are chasing after them, creating one of the hottest corners of dealmaking in the industry.Also read | India's out-of-pocket healthcare spending drops significantly, govt data showsIt's not unusual for exciting new drugs to spark surges in stock prices and dealmaking frenzy. But molecular glue is a particularly complicated science, and the startups pursuing technologies similar to RevMed are mostly in early stages of testing. Their medicines won't be ready for years, if ever.That hasn't stopped big drugmakers such as Novartis, Roche Holding and Eli Lilly from inking research pacts with glue developers that could pay out billions of dollars in milestones.The boom has been especially lucrative for Monte Rosa Therapeutics. Over the past three years, the Boston-based biotech firm has signed three agreements that could be worth over $10 billion to develop molecular glue drugs with both Novartis and Roche.The company, which trades under the stock ticker GLUE, has seen its shares surge nearly 400% over the past year. It's preparing to start mid-stage trials for multiple drugs by the end of this year."The run-up in the share price is justified based on what we've seen so far," says Robert Driscoll, an analyst at Wedbush. Gains are "due to the success of their drugs rather than kind of exuberance around the glue technology as a whole", he says.Science of GlueMolecular glues work in a fundamentally different way from other oral medicines. Most pills - like Prozac for depression or Lipitor for cholesterol - are tiny chemicals that squeeze into a pocket inside a much larger protein to gum up its functioning. But many proteins have few obvious pockets, including key cancer-causing proteins.In fact, about 80% of all proteins in the body are what scientists refer to as "undruggable", meaning they can't be targeted with traditional drug technologies.RevMed's daraxonrasib cleverly circumvents this problem by acting as a molecular stickum. Once inside the body it binds to a healthy protein on one side and then draws in the bad protein to stick to the other side. The healthy protein helps block the bad protein and turn off its signalling.Competitors Line UpMultiple companies are chasing RevMed's lead in pancreatic cancer despite the long odds. San Diego-based Erasca is in early stages of testing a drug it says is more potent than daraxonrasib. Japanese drugmaker Astellas Pharma has begun final-stage trials of a degrader that may help a subset of pancreatic and lung cancer patients.Molecular glues are also being developed as alternatives to injectable drugs used to treat autoimmune and skin disorders. Shares of Kymera Therapeutics have soared more than 180% in the past year thanks to promising early trial results. The company is developing a once-daily pill it hopes will one day compete with Sanofi and Regeneron Pharmaceuticals' Dupixent, one of the world's bestselling drugs."The technology allows you to go after things that would have been almost impossible" to do previously with pills, says Nello Mainolfi, Kymera's founder and CEO.With few effective options for pancreatic cancer, analysts expect RevMed's daraxonrasib to become an enormous bestseller for the company.Prospects for daraxonrasib and speculation about a potential takeout deal have inflated RevMed's market cap to nearly $33 billion. That's a lofty figure for a drugmaker with no approved medicines.The company is preparing to file for US approval soon, and the FDA has promised to give the drug an ultrafast review. It's projected to reach $7 billion in sales a year by 2032, according to the average of estimates compiled by Bloomberg.

With new message, Trump stirs Iran pot again

US President Donald Trump said on May 29 that Iran must commit to never developing a nuclear weapon and ensure unrestricted shipping movement through the Strait of Hormuz, while indicating that discussions involving Tehran, Washington and international agencies were moving towards a possible understanding on key security issues in the region.In a post on Truth Social, Trump said the Strait of Hormuz should remain open without any restrictions or tolls for commercial shipping traffic in both directions. He also claimed that naval restrictions imposed earlier in the region would be lifted, allowing stranded ships to resume movement.Trump further said any water mines present in the strategic waterway would be removed or destroyed in coordination with Iranian authorities. He claimed that US naval operations had already neutralised several mines in the region.Also read | US inflation rises to 3.8% in April, highest level in nearly 3 years"The enriched material, sometimes referred to as “Nuclear Dust,” which is buried deep underground with virtually collapsed mountains, caused by our powerful B2 Bomber attack 11 months ago, sitting on top of it, will be unearthed by the United States (which, it is agreed, is the only Country, along with China, with the mechanical capability of doing so!), in close coordination and conjunction with the Islamic Republic of Iran, plus the International Atomic Energy Agency, and DESTROYED. No money will be exchanged, until further notice. Other items, of far less importance, have been agreed to," Trump's post read."I will be meeting now, in the Situation Room, to make a final determination. Thank you for your attention to this matter!" he signed off.The remarks come amid heightened geopolitical tensions in West Asia and renewed global concerns over Iran’s nuclear programme, maritime security and crude oil supply disruptions. The Strait of Hormuz remains one of the world’s most critical oil transit chokepoints, handling a significant share of global crude and LNG shipments.Any disruption in the waterway has historically triggered volatility in international oil markets and raised concerns among major energy-importing nations, including India.Also read | US goods trade deficit narrows in April on strong exportsTrump also referred to Iran’s enriched nuclear material, saying the stockpile buried underground after a previous US B-2 bomber strike would be excavated and destroyed under international supervision. He said the process would involve close coordination between the United States, Iran and the International Atomic Energy Agency (IAEA).According to Trump, no financial exchange would take place as part of the proposed arrangement until further decisions are taken. He added that several other issues had also been agreed upon, though he did not elaborate on details.The former US president said he would meet officials in the Situation Room before taking a final decision on the matter.The comments assume significance as tensions between the US and Iran have remained elevated over Tehran’s nuclear activities, sanctions and regional security concerns. Recent developments in the Middle East have also intensified fears of escalation that could impact global trade routes and energy prices.International crude oil markets have remained highly sensitive to developments surrounding Iran and the Strait of Hormuz. Analysts have warned that any prolonged uncertainty in the region could affect fuel prices, shipping costs and supply chains globally.India, which imports a majority of its crude oil requirements, closely monitors developments in the Gulf region as volatility in oil prices has direct implications for inflation, fuel costs and the country’s trade balance.

GT vs RR, IPL 2026 Qualifier 2: What happens if rain washes out the match?

Rain threatens the Gujarat Titans vs Rajasthan Royals Qualifier 2. If a washout occurs, the IPL has a contingency plan involving extra time, reduced overs, or a Super Over. Should no play be possible, the team higher in the league standings, Gujarat Titans, will advance to the final.

‘Not there yet, but very close,’ says JD Vance on possible US-Iran deal - 'Hopefully, we'll continue to make progress'

Iran US News: US vice president JD Vance told reporters in Washington DC that the US believed the Iranians were negotiating in 'good faith'.

Quote of the Day by Oscar Wilde: ‘The only possible society is oneself’ —Why self-acceptance matters

Oscar Wilde's quote emphasises the importance of self-acceptance over societal approval. He suggests that true individuality and inner peace stem from valuing oneself, rather than seeking validation from others, which is crucial in today's comparison-driven world.

'Never Thought I'd Become A Politician': Siddaramaiah's Farewell Message After Resigning As Karnataka CM

Karnataka CM Siddaramaiah resigns, says he followed Congress high command orders, resignation awaits Governor Thaawarchand Gehlot, DK Shivakumar seen as possible successor.

Chandrayaan-2 finds possible subsurface ice on Moon. What we know

Since these regions are continuously shielded from both sunlight and thermal radiation, temperatures there remain extremely low, around 25 Kelvin.

ISRO Detects Possible Ice Beneath Moon's Surface Using Chandrayaan-2 Data

Scientists used advanced radar polarimetric methods to study the craters.

ISRO Detects Possible Subsurface Ice On Moon’s South Pole Using Chandrayaan-2 Data

Among the craters examined, scientists found particularly strong evidence of subsurface ice in a 1.1-kilometre-wide crater located within the larger Faustini crater.

PM Modi urges citizens to take all possible precautions amid soaring mercury

PM Modi urged everyone to stay hydrated and not to ignore the warning signs of heat exhaustion as it can quickly turn dangerous and may even lead to heatstroke

No CM Change In Karnataka For Now: Congress Says Discussions Only Focused On Rajya Sabha Elections

Karnataka CM Siddaramaiah and his deputy DK Shivakumar were summoned by the Congress leadership in New Delhi amid growing buzz over a possible leadership change in the state.

UDF government will scrutinise steps taken by previous LDF government in MSC Elsa 3 disaster, says V.D. Satheesan

Chief Minister says government closely monitoring fuel price hike and its possible impact on common man

India-China issues, impact of global conflicts, and the role of middle powers in spotlight at Huddle 2026

The theme of this year’s Huddle set to be held in Bengaluru on June 5 and 6 is ‘The World in Transition’; senior diplomats and experts on global affairs will discuss possible solutions to conflicts in West Asia and Europe

Area, district hospitals get a pat for performing complex surgeries

Director of Secondary Health sends appreciation letters to 50 government hospitals for providing best possible medical care to patients despite certain limitations

Centre offering Ladakh unique governance model, demand for Statehood to continue: Leh Apex Body leader

Cherring Dorjay Lakruk, co-convenor of the Leh Apex Body, says, “We are not abandoning our demand for Statehood. Even if at present, Statehood is not possible, we will continue with the demand.”