Spatial Disease Mapping and Disparity Detection Using Generative AI: An Amortized Bayesian Learning Framework

Statistics > Methodology [Submitted on 16 Jun 2026] Title:Spatial Disease Mapping and Disparity Detection Using Generative AI: An Amortized Bayesian Learning Framework View PDF HTML (experimental)Abstract:We introduce an amortized Bayesian framework for spatial boundary detection that generalizes posterior inference across areal graphs with varying numbers of regions and diverse adjacency structures. The underlying model couples a Poisson count likelihood with a covariate-driven rule to interrupt smoothing across dissimilar neighboring areas, utilizing a directed acyclic graph autoregressive (DAGAR) prior to capture residual spatial dependence. To approximate the target posterior distribution, a neural engine is trained on simulated maps: a permutation-invariant summary network encodes graph-aware representations of the observed counts, offsets, covariates, and adjacency matrices, while a conditional normalizing flow generates the approximate posterior draws. Simulation studies demonstrate accurate parameter recovery, near-nominal interval coverage, well-calibrated posterior predictive behavior, and informative posterior boundary probabilities. Benchmarking against Markov chain Monte Carlo (MCMC) confirms close agreement regarding primary boundary evidence, and an ablation study validates the inclusion of model-guided graph summaries. Finally, applications to Glasgow respiratory disease and California lung cancer data demonstrate that a single trained neural engine can be seamlessly deployed across real-world maps with distinct graph structures, yielding boundary conclusions consistent with established localized smoothing analyses. Submission history From: Luca Aiello Ph.D. [view email][v1] Tue, 16 Jun 2026 16:45:39 UTC (7,749 KB) References & Citations Loading... Bibliographic and Citation Tools Bibliographic Explorer (What is the Explorer?) Connected Papers (What is Connected Papers?) Litmaps (What is Litmaps?) scite Smart Citations (What are Smart Citations?) Code, Data and Media Associated with this Article alphaXiv (What is alphaXiv?) CatalyzeX Code Finder for Papers (What is CatalyzeX?) DagsHub (What is DagsHub?) Gotit.pub (What is GotitPub?) Hugging Face (What is Huggingface?) ScienceCast (What is ScienceCast?) Demos Recommenders and Search Tools Influence Flower (What are Influence Flowers?) CORE Recommender (What is CORE?) arXivLabs: experimental projects with community collaborators arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.