Scientists uncover two neuronal circuits orchestrating muscle autophagy

Autophagy is the process by which cells remove damaged proteins, recycle worn-out organelles (e.g., mitochondria), clear cellular waste and provide nutrients during stress.

Autophagy is essential for muscles because they are constantly under mechanical stress.

If autophagy is too low, damaged proteins accumulate and muscle gradually weakens.

If it is too high, muscle tissue can begin breaking itself down. ...