Hidden mechanism driving joint tissue growth in rheumatoid arthritis has been found

Researchers at Hospital for Special Surgery (HSS) have identified a specialized population of immune cells that plays a central role in driving abnormal tissue growth in rheumatoid arthritis (RA), offering new insight into disease progression and potential treatment strategies.

The study, published in Science Translational Medicine, reveals that a subset of immune cells known as SPP1ʰⁱ macrophages works in tandem with structural cells and protein scaffolds to promote excessive tissue expansion in the joints of patients with RA. ...