A substitution lemma for multiple context-free languages

We present a necessary condition for an infinite language to be multiple context-free, which we call a Substitution Lemma. We apply it to show a sample selection of languages are not multiple context-free, including the word problem of the group $F_2\times F_2$. We also show that groups with multiple context-free word problem have decidable rational subset membership problem.
Our result contrasts with previous work showing that the standard pumping lemma for context-free languages cannot be generalised to multiple context-free languages, and that weak variants of generalised Ogden's lemma do not apply to multiple context-free languages.