New screening tool spots RNA-disrupting antibiotics for drug-resistant gram-negative bacteria

Researchers from Skoltech and other science centers in Russia have developed a reporter system—a tool for screening potential new antibiotics—that enables the selection of drug compounds disrupting RNA synthesis in gram-negative bacteria.

Among others, these include multidrug-resistant Pseudomonas aeruginosa, a dangerous pathogen responsible for hospital-acquired infections that has already adapted to existing antibiotics. ...