Disabling SagA enzyme in VREfm infections makes drug-resistant bacteria vulnerable to vancomycin

Antibiotic resistance is one of the most urgent threats to global health, linked to an estimated 4.7 million deaths worldwide in 2019 alone.

As more bacteria evolve to evade even last-resort drugs, the supply of effective treatments is shrinking.

Now, scientists at Scripps Research have discovered a way to restore the effect of one of those critical antibiotics by disabling a key bacterial enzyme. ...