After amyloid plaques form, tau and alpha-synuclein pathology rises in mice

The aging brain frequently harbors multiple protein pathologies that contribute to Alzheimer's, Parkinson's and other neurodegenerative diseases.

But how do these problematic proteins interact with each other, and could these interactions inform future therapies?

Researchers at TGen, part of City of Hope, are answering some of these questions with the help of a unique mouse model that combines different mixtures of dementia-related proteins including amyloid-beta, alpha-synuclein and tau. ...