New protein structure reveals cancer signaling mechanism and potential drug target

Malignant melanoma is one of the most dangerous forms of cancer.

Around half of melanomas and about 7% of all other cancers carry a mutation in a protein called BRAF.

This mutation disrupts the regulation of cell division, causing cells to multiply in an uncontrolled manner.

Researchers at PSI and the University of Zurich have now examined the BRAF protein in greater detail, gaining valuable insights into its complex regulation. ...