Aging induced structural alterations in SR-Mitochondria interaction in skeletal muscle: Emerging insights

Quantitative Biology > Subcellular Processes [Submitted on 16 Jun 2026] Title:Aging induced structural alterations in SR-Mitochondria interaction in skeletal muscle: Emerging insights View PDFAbstract:Skeletal muscle undergo remarkable changes during aging including anatomical, ultrastructural, and moreover biochemical. The aging associated reduction of muscle mass, termed as sarcopenia, is a major factor in geriatric functional decline and frailty, contributing to the lowering of self-confidence. In an adult skeletal muscle fibers, sarcoplasmic reticulum (SR) and mitochondria exhibit most intricate and precise distribution along with the sarcolemmal (forming T-tubule), which is critical for muscle function. In healthy young muscle tissue, the close physical proximity of SR and mitochondrial membranes shows contacts called mitochondria-associated membranes (MAMs). Recent literature highlights the role of MAMs network in smooth functioning of muscle by regulating localization of Ca2+-signaling, lipid transport, and other signalling molecules like reactive oxygen species. Several tethering mechanisms are proposed to stabilize the MAMs network, the classical ones being the mitofusins (MFN1 and MFN2). Emerging consensus suggest that MAMs in the skeletal muscle facilitate accuracy of excitation-metabolic coupling ensuring spatial energy supply. However, upon aging the precision of SR and mitochondria co-localization as well as crosstalk seems to be affected. In this review, we have critically examined the current literature about MAMs network structure and function during health and diseases mainly from an aging perspective. We have further evaluated the role of exercise, nutritional, nutraceutical and pharmacological approaches in lowering MAMs loss in an effort to retard aging progression. Retention of skeletal muscle health and performance is a major factor in achieving the goal of healthy aging. References & Citations Loading... Bibliographic and Citation Tools Bibliographic Explorer (What is the Explorer?) Connected Papers (What is Connected Papers?) Litmaps (What is Litmaps?) scite Smart Citations (What are Smart Citations?) Code, Data and Media Associated with this Article alphaXiv (What is alphaXiv?) CatalyzeX Code Finder for Papers (What is CatalyzeX?) DagsHub (What is DagsHub?) Gotit.pub (What is GotitPub?) Hugging Face (What is Huggingface?) ScienceCast (What is ScienceCast?) Demos Recommenders and Search Tools Influence Flower (What are Influence Flowers?) CORE Recommender (What is CORE?) arXivLabs: experimental projects with community collaborators arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.