Alzheimer’s breakthrough: Scientists restore two hours of sleep without clearing brain plaques

Researchers have uncovered a surprising culprit behind sleep loss in Alzheimer’s disease: the brain’s own immune cells.

In mice with amyloid plaques, overactive microglia triggered inflammation that kept the brain from getting enough deep, restorative sleep.

Temporarily removing most of these cells restored more than two hours of sleep per day, even though the plaques remained unchanged. ...