New framework renders AI more trustworthy for cancer subtyping

Medical artificial intelligence (AI) faces a fundamental challenge: uncertainty quantification.

Artificial neural networks are largely unaware of the limits of their training data and can become overconfident when confronted with unfamiliar inputs.

Suppose you train a neural network to distinguish among African mammals.

If you then present it with an image of a South American jaguar—an animal it has never encountered—the model cannot say "unknown." Instead, it may confidently declare the jaguar to be a leopard. ...