Inflammation may trigger protective cell shift in ulcerative colitis, study finds

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Inflammation may trigger protective cell shift in ulcerative colitis, study finds

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Paneth cell metaplasia (PCM), long viewed as a consequence of chronic inflammation in ulcerative colitis, may also help protect and repair the intestine, according to researchers at Science Tokyo.

The study found that inflammation increases IL-22 signaling, which promotes PCM and the production of REG3A, a protein that helps heal the intestinal lining.

The findings suggest PCM may be a protective response but should be monitored because persistent PCM could increase cancer risk. ...

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Inflammation may trigger protective cell shift in ulcerative colitis, study finds

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