Metabolite glues as a means of purine sensing and chemotherapeutic response

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10790-3
Purines can act as endogenous molecular glues in human cells by anchoring a rate-limiting enzyme in purine biosynthesis to its inhibitor, and modifying this mechanism could provide a way to improve the properties of thiopurine chemotherapeutic drugs. ...