AI identifies interactions in CRISPR complexes to improve specificity of DNA editing

Nature

Nature, Published online: 22 July 2026; doi:10.1038/d41586-026-02042-1
AlphaFold3 predictions of the molecular contacts made by a genome-editing enzyme have been used to improve the enzyme’s selectivity for target DNA sequences. ...

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AI identifies interactions in CRISPR complexes to improve specificity of DNA editing

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