Uncovering the structure of the poxvirus 'portal complex'

Poxviruses have a long history in human disease as well as medicine: The first-ever vaccine was developed to protect against smallpox, which has since been eradicated.

Despite this, scientists still don't fully understand how poxviruses infect and replicate inside our cells.

Recent outbreaks of mpox highlight an urgent need to better understand poxvirus biology. ...