New PPAR therapies could slow fibrosis in primary biliary cholangitis

Primary biliary cholangitis is a rare autoimmune disease that affects the liver and can progress to cirrhosis.

It occurs when the immune system attacks the small bile ducts within the liver.

As a result, bile builds up, leading to inflammation and progressive liver damage.

Although a first-line treatment exists, 40% of patients do not respond adequately to it or cannot tolerate it, so new treatment options need to be developed. ...