How systemic immune regulation is 'hijacked' during tumor progression

The immune system plays a critical role in protecting the body from cancer by recognizing and eliminating abnormal cells before they can develop into tumors.

This process relies on T cells that can recognize tumor-derived antigens presented by dendritic cells (DCs).

However, tumor cells frequently evade immune surveillance and establish immune tolerance through various mechanisms, most of which are thought to occur within the tumor microenvironment. ...