Combination therapy improves progression-free survival for patients with metastatic dMMR colorectal cancer

Patients with deficient DNA mismatch repair (dMMR) or microsatellite instability-high (MSI-H) metastatic colorectal cancer experienced a 58% reduction in the risk of disease progression or death when treated with atezolizumab (Tecentriq) plus modified FOLFOX6 and bevacizumab (Avastin), compared with atezolizumab alone, according to results from the NRG-GI004/SWOG S1610 COMMIT trial published in the Journal of Clinical Oncology.

The combination also produced higher response rates and substantially reduced primary disease progression. ...