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CRISPR–Cas regulates expression of embedded anti-phage defence systems

Nature

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10833-9
CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate these defences when compromised, establishing a layered bacterial ‘immunity guard’ network. ...

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