Gut immune cells may help explain how B-cell depletion controls MS

B-cell depletion therapies, in which B cells of the immune system that may drive disease activity in multiple sclerosis (MS) are temporarily removed, have contributed significantly to improved treatment for patients in recent years.

Researchers from the University Hospital of Bonn (UKB), the Universities of Bonn, Basel, Toronto and Yale, along with their collaborators, have uncovered a previously unknown mechanism through which B-cell depletion therapies contribute to a better disease course in patients with MS. ...