Hidden kidney effects emerge in LRBA deficiency, with polyuria in some patients

LRBA deficiency has long been viewed primarily as an immune disorder, but researchers at Science Tokyo have found that the condition may also impair urinary concentrating ability.

Using patient registry data from 43 individuals, mouse models and protein analysis, the study found that LRBA deficiency can cause excessive urination and electrolyte abnormalities, highlighting the need for closer fluid and sodium monitoring in affected patients. ...